H
Hans Grönlund
Researcher at Karolinska Institutet
Publications - 117
Citations - 5494
Hans Grönlund is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Immunoglobulin E & Fel d 1. The author has an hindex of 42, co-authored 109 publications receiving 4889 citations. Previous affiliations of Hans Grönlund include Vienna General Hospital & Karolinska University Hospital.
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Journal ArticleDOI
Vaccination with genetically engineered allergens prevents progression of allergic disease
Verena Niederberger,Friedrich Horak,Susanne Vrtala,Susanne Spitzauer,Maria Theresa Krauth,Peter Valent,Jürgen Reisinger,M. Pelzmann,Brigitte Hayek,M. Kronqvist,Guro Gafvelin,Hans Grönlund,Ashok Purohit,Roland Suck,H. Fiebig,Oliver Cromwell,Gabrielle Pauli,M. van Hage-Hamsten,Rudolf Valenta +18 more
TL;DR: Rises of allergen-specific IgE induced by seasonal birch pollen exposure were significantly reduced in vaccinated patients, and vaccination with genetically engineered allergenic derivatives is a therapy for allergy that not only ameliorates allergic reactions but also reduces the IgE production underlying the disease.
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Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis.
Ivan Jelcic,Faiez Al Nimer,Faiez Al Nimer,Jian Wang,Verena Lentsch,Raquel Planas,Ilijas Jelcic,Aleksandar Madjovski,Sabrina Ruhrmann,Wolfgang Faigle,Katrin Frauenknecht,Clemencia Pinilla,Radleigh G. Santos,Christian Hammer,Christian Hammer,Yanneth Ortiz,Lennart Opitz,Hans Grönlund,Gerhard Rogler,Onur Boyman,Richard Reynolds,Andreas Lutterotti,Mohsen Khademi,Tomas Olsson,Frederik Piehl,Mireia Sospedra,Roland Martin +26 more
TL;DR: It is demonstrated that self-reactivity, defined as “autoproliferation” of peripheral Th1 cells, is elevated in patients carrying the HLA-DR15 haplotype, and RASGRP2 is identified as target autoantigen that is expressed in the brain and B cells.
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Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injections
Gabriela Senti,Reto Crameri,Daniela Kuster,Pål Johansen,Julia M. Martinez-Gomez,Nicole Graf,Martin Dr. Steiner,Ludwig A. Hothorn,Hans Grönlund,Christine Tivig,Anna Zaleska,Ozge Soyer,Marianne van Hage,Cezmi A. Akdis,Mübeccel Akdis,H. Rose,Thomas M. Kündig +16 more
TL;DR: In a first-in-human clinical study ILIT with MAT-Fel d 1 was safe and induced allergen tolerance after 3 injections, and was also positively correlated with IL-10 production.
Journal ArticleDOI
Peptide immunotherapy in allergic asthma generates IL-10–dependent immunological tolerance associated with linked epitope suppression
John D. Campbell,Karen F. Buckland,Sarah J. McMillan,Jennifer Kearley,William L. G. Oldfield,Lawrence J. Stern,Hans Grönlund,Marianne van Hage,Catherine J. Reynolds,Rosemary J. Boyton,Stephen P. Cobbold,A. Barry Kay,Daniel M. Altmann,Clare M. Lloyd,Mark Larché,Mark Larché +15 more
TL;DR: In vivo evidence of linked epitope suppression and IL-10 induction in both human allergic disease and a mouse model designed to closely mimic peptide therapy in humans is provided.
Journal ArticleDOI
Identification of galactose-α-1,3-galactose in the gastrointestinal tract of the tick Ixodes ricinus; possible relationship with red meat allergy.
Carl Hamsten,Maria Starkhammar,Thi Anh Thu Tran,Magnus Johansson,Ulf Bengtsson,Gustaf Ahlén,Matti Sällberg,Hans Grönlund,M. van Hage +8 more
TL;DR: The first direct evidence that α‐Gal is present within ticks is provided thus potentially explaining the relationship between tick exposure and sensitization to α‐ Gal, with development of red meat allergy as a secondary phenomena.