T
Tao Zhang
Researcher at Xi'an Jiaotong University
Publications - 66
Citations - 1184
Tao Zhang is an academic researcher from Xi'an Jiaotong University. The author has contributed to research in topics: Degranulation & Histamine. The author has an hindex of 19, co-authored 62 publications receiving 840 citations.
Papers
More filters
Journal ArticleDOI
Recent advances in cell membrane chromatography for traditional Chinese medicines analysis
Xiaofang Hou,Sicen Wang,Tao Zhang,Jing Ma,Jie Zhang,Yanmin Zhang,Wen Lu,Huaizhen He,Langchong He +8 more
TL;DR: Some of the latest progress and applications about CMC including instrument development, research on drug-receptor interactions, screening active components from TCMs, and quality control of TCMs are reviewed.
Journal ArticleDOI
Typical antimicrobials induce mast cell degranulation and anaphylactoid reactions via MRGPRX2 and its murine homologue MRGPRB2.
Tao Zhang,Delu Che,Rui Liu,Shengli Han,Nan Wang,Nan Wang,Yingzhuan Zhan,Yingzhuan Zhan,Priyanka Pundir,Jiao Cao,Yanni Lv,Liu Yang,Jue Wang,Meiwen Ding,Xinzhong Dong,Langchong He +15 more
TL;DR: It is shown that MRGPRX2 is involved in allergic‐like reactions to three types of antimicrobials in a dose‐dependent manner, which should alarm many clinicians that such drugs might induce anaphylactoid reactions and provide guidance on safe dosage of these drugs.
Journal ArticleDOI
Saikosaponin A inhibits compound 48/80-induced pseudo-allergy via the Mrgprx2 pathway in vitro and in vivo
Nan Wang,Delu Che,Tao Zhang,Rui Liu,Jiao Cao,Jue Wang,Tingting Zhao,Pengyu Ma,Xinzhong Dong,Langchong He +9 more
TL;DR: SSA could inhibits IgE‐independent allergy, but not IgE-dependent allergy, and this effect involves the Mrgprx2 pathway, a new sight on pseudo‐allergy and its therapy.
Journal ArticleDOI
MRGPRX2 is essential for sinomenine hydrochloride induced anaphylactoid reactions.
Rui Liu,Delu Che,Tingting Zhao,Priyanka Pundir,Jiao Cao,Yanni Lv,Jue Wang,Pengyu Ma,Jia Fu,Nana Wang,Xiaoyang Wang,Tao Zhang,Xinzhong Dong,Langchong He +13 more
TL;DR: Results showed a kind of mechanism that SH‐induced anaphylactoid reactions were mediated by MRGPRX2 via activating PLC molecular signaling pathways to provoke mast cells Ca2+ mobilization and degranulation.
Journal ArticleDOI
Quercetin inhibits Mrgprx2-induced pseudo-allergic reaction via PLCγ-IP3R related Ca2+ fluctuations.
Yuanyuan Ding,Delu Che,Chaomei Li,Jiao Cao,Jue Wang,Pengyu Ma,Tingting Zhao,Hongli An,Tao Zhang +8 more
TL;DR: Evaluated in vivo and in vitro Quercetin was validated as an effective small molecule inhibiting Mrgprx2‐induced pseudo‐allergic reaction via PLC&ggr;‐IP3R associated Ca2+ fluctuations, thus highlighting a potential candidate to suppress MrgPRx2 induced pseudo-allergic related diseases.