Showing papers in "International Immunopharmacology in 2019"

TL;DR: Some inhibitors of NLRP3 inflammatory pathways are focused on to alleviate the progression of PD by inhibiting central inflammation and provide new therapeutic strategies for the treatment of PD.

TL;DR: Recent studies on several naturally occurring compounds that may possess the ability to regulate macrophage polarization are summarized and the associated molecular mechanisms explored.

TL;DR: Recent scientific discoveries of pyroptosis's involvement in atherosclerosis, myocardial infarction, diabetic cardiomyopathy, reperfusion injury and myocarditis are summarized and new and emerging evidence suggesting that pyroPTosis signaling pathways may be potential therapeutic targets in cardiovascular diseases are organized.

TL;DR: Findings indicate that BMSC-derived exosomes can attenuate inflammation and demyelination of the CNS in the EAE rat model by regulating the polarization of microglia, and may be a potential therapeutic approach for the treatment of autoimmune and inflammatory diseases.

TL;DR: Evidence is provided that berberine hydrochloride might be a useful herb medicine and serve as a promising novel therapy in the treatment of UC in humans.

TL;DR: The pharmacological effects anti-inflammatory, neuroprotective, anti-tumor,Anti-cardiovascular diseases, and associated mechanisms of action of paeonol up to date are summarized.

TL;DR: It is shown that the expression of GSDMD was consistently correlated with CD8+ T cell markers in The Cancer Genome Atlas (TCGA) cohorts and demonstrated that G SDMD is required for an optimal CTL response to cancer cells.

TL;DR: EVs from cultured medium of bone‐marrow mesenchymal stem cells transfected with recombinant lentiviruses can serve as a stable delivery system and overexpress miR‐146a, which significantly inhibited TNF receptor–associated factor 6 (TRAF6) and IL‐1 receptor‐associated kinase 1 (IRAK1) expression in TNBS‐induced colitis of rats.

TL;DR: PD-1 and PD-L1 studies have significantly increased after 2014 and further research should expand and develop new topics such as those likely to boost therapeutic strategies for cancer.

TL;DR: MCC950, as a specific NLRP3 inhibitor, can alleviate fibrosis and improve cardiac function in a mouse model by suppressing early inflammatory responses post-MI.

TL;DR: It is demonstrated that curcumin exerts therapeutic effects on arthritis in CIA rats and has a strong pharmacological activity on reducing the inflammatory response in macrophages.

TL;DR: Egg yolk constitutes a relevant alternative source of antibodies and is more suitable for diagnostic purposes than mammalian antibodies, since it does not react with certain components of the human immune system and displays greater avidity for mammalian conserved proteins.

TL;DR: Baicalin may have a regulating effect on IKK/IKB/NF-kB signaling pathway and apoptosis-related proteins in UC rats.

TL;DR: Investigation of the effects of GA on IL-1β-induced HIEC-6 cells and TNBS-induced UC in mice demonstrated that GA plays an anti-inflammatory role in UC via inhibiting NF-κB pathway.

TL;DR: The data shows that EP-1 was effective in relieving the symptoms of acetic acid induced UC rats and the polysaccharide purified from HE showed potential for anti-UC activity and the complementary and alternative medicine (CAM) herb therapy.

TL;DR: Celastrol can improve the recovery of hindlimb motor function after SCI in Sprague‐Dawley (SD) rats, and reduce the cavity area of spinal cord injury along with the neuronal loss.

TL;DR: BMSC-derived EVs exerted positive therapeutic effects against DSS-induced UC, which could be due to a negative inflammatory response, and the positive effect of EVs on UC repair seemed to be related to the JAK1/ STAT1/STAT6 signaling pathway.

TL;DR: The results show that L-fucose can attenuate colitis by inhibiting macrophage M1 polarization, inhibiting NLRP3 inflammasome and NF-kB activation, and down-regulation of pro-inflammatory cytokines.

TL;DR: It is revealed that curcumin relieves a depressive-like state through the inhibition of the NLRP3 inflammasome and kynurenine pathway.

TL;DR: Linalool effectively exerts a protective role in OVA-induced airway inflammation and mucus hypersecretion, and its protective effects are closely related to the downregulation of inflammatory mediators and MAPKs/NF-κB signaling.

TL;DR: It is suggested that luteoloside might be an effective treatment for cerebral ischemia and other neurological disorders after exerting a protective effect on cerebral ischemic injury induced by MCAO in rats.

TL;DR: These findings provide novel insight into the anticancer effects of baicalein and baicalin through which tumor growth is inhibited by PD-L1 expression downregulation and suggest that these flavonoids have great potential for clinical treatment.

TL;DR: Collectively, diosgenin ameliorates testicular damage in DM, at least via partial suppression of apoptosis, oxidative stress, inflammation, and neutrophil infiltration and also via partial restoration of mitochondrial integrity.

TL;DR: Butyrate administration inhibited arthritis in CIA mice model, suppressed the expression of inflammatory cytokines, and influenced the function of Th17 cells.

TL;DR: Results suggest that inhibiting GSK‐3&bgr; downregulates NLRP3 inflammasome expression by increasing autophagic activity in cerebral ischemia reperfusion injury.

TL;DR: Bioinformatics data elucidate that anti‐LI pharmacological activities of VC may be predominantly related to inhibition of inflammatory stress, contributing to suppression of LI development, and highlight the predicted therapeutic targets may be potential biomarkers for anti-LI.

TL;DR: The study suggests that the downregulated lncRNA UCA1 ameliorates the damage of dopaminergic neurons, reduces oxidative stress and inflammation in PD rats through the inhibition of the PI3K/Akt signaling pathway.

TL;DR: The effects of ART in vitro and in vivo were investigated to determine how it influences the anti‐tumor immune response and the enhanced anti‐cancer immunity was associated with suppression of Tregs and MDSCs in the tumor.

TL;DR: It was found that genistein can significantly improve IMQ‐induced pathological scores of cutaneous skin lesions in mice, reduce epidermal thickness, and inhibit the expression of inflammatory factors, including interleukin (IL)‐1&bgr;, IL‐6, tumour necrosis factor‐alpha (TNF‐&agr;), chemokine ligand 2 (CCL2), IL‐17 and IL‐23.

TL;DR: It is demonstrated that lncRNA NEAT1 interacts with Let-7a, targeting TLR4 to contribute to the LPS-induced inflammatory response, and can provide a potential therapeutic target for sepsis-induced liver injury.