T
Tarja Toimela
Researcher at University of Tampere
Publications - 46
Citations - 976
Tarja Toimela is an academic researcher from University of Tampere. The author has contributed to research in topics: Cell culture & Angiogenesis. The author has an hindex of 19, co-authored 42 publications receiving 881 citations. Previous affiliations of Tarja Toimela include National Institute of Chemical Physics and Biophysics.
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Refining in vitro neurotoxicity testing--the development of blood-brain barrier models.
TL;DR: The purpose of this paper is to review the current state of development of advanced in vitro blood–brain barrier (BBB) models and to suggest a novel three-dimensional technique for the screening of neurotoxic compounds.
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Intra-laboratory validated human cell-based in vitro vasculogenesis/angiogenesis test with serum-free medium.
Tarja Toimela,Outi Huttala,E. Sabell,Marika Mannerström,Jertta-Riina Sarkanen,Timo Ylikomi,Tuula Heinonen +6 more
TL;DR: A serum-free human adipose stromal cell and umbilical cord vein endothelial cell based vasculogenesis/angiogenesis test that has great potential to be a screening test for prioritization purposes of chemicals and a test in a battery to predict developmental hazards in a regulatory context is developed.
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Development of Versatile Human In Vitro Vascularized Adipose Tissue Model with Serum-Free Angiogenesis and Natural Adipogenesis Induction.
Outi Huttala,Maaria Palmroth,Pauliina Hemminki,Tarja Toimela,Tuula Heinonen,Timo Ylikomi,Jertta-Riina Sarkanen +6 more
TL;DR: A vascularized adipose tissue model is developed where human adipose stromal cells and human umbilical cord vein endothelial cells were cocultured with natural adipogenic and defined serum‐free angiogenic media for 14 days, producing strong lipid accumulation, good vascular network formation and induced adipocyte‐specific protein secretion and expression of studied adipocyte genes.
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Comparison of an automated pattern analysis machine vision time-lapse system with traditional endpoint measurements in the analysis of cell growth and cytotoxicity.
TL;DR: The results showed that the automated system for pattern analysis of morphological changes yielded comparable results to those obtained by conventional methods, as compared to conventional endpoint measurement methodology.
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In vitro methods as a tool in neurotoxicity studies
TL;DR: When used appropriately with in vivo tests and with previous toxicological data, in vitro neurotoxicity testing considerably improves risk assessment and can reduce the number of animals used in routine toxicity testing, by identifying chemicals with high neurotoxic potential.