抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Between Facts and Norms: Contributions to a Discourse Theory of Law and Democracy

By Pierre Bourdieu (London: Routledge, 2010), xxx + 607 pp. £15.99 paper. A combination of social theory, statistical data, illustrations, and interviews, Distinction: A Social Critique of the Judg...

Distinction: A Social Critique of the Judgement of Taste

Online content providers such as YouTube are carefully positioning themselves to users, clients, advertisers and policymakers, making strategic claims for what they do and do not do, and how their place in the information landscape should be understood. One term in particular, ‘platform’, reveals the contours of this discursive work. The term has been deployed in both their populist appeals and their marketing pitches, sometimes as technical ‘platforms’, sometimes as ‘platforms’ from which to speak, sometimes as ‘platforms’ of opportunity. Whatever tensions exist in serving all of these constituencies are carefully elided. The term also fits their efforts to shape information policy, where they seek protection for facilitating user expression, yet also seek limited liability for what those users say. As these providers become the curators of public discourse, we must examine the roles they aim to play, and the terms by which they hope to be judged.

http://www.itu.dk/people/irsh/DMOK/Gillespie_10_PoliticsPlatforms.pdf

The politics of ‘platforms’

Deciding What's News: A Study of CBS Evening News, NBC Nightly News, Newsweek, and Time

This chapter contains section titled: Patterns of Inclusion, Cycles of Anticipation, The Evaluation of Relevance, The Promise of Algorithmic Objectivity, Entanglement with Practice, The Production of Calculated Publics, Conclusion, Acknowledgments, Notes

/pdf/the-relevance-of-algorithms-3kslccydqd.pdf

The Relevance of Algorithms

In recent years, scholarship around media technologies has finally shed the assumption that these technologies are separate from and powerfully determining of social life, looking at them instead as produced by and embedded in distinct social, cultural, and political practices. Communication and media scholars have increasingly taken theoretical perspectives originating in science and technology studies (STS), while some STS scholars interested in information technologies have linked their research to media studies inquiries into the symbolic dimensions of these tools. In this volume, scholars from both fields come together to advance this view of media technologies as complex sociomaterial phenomena. The contributors first address the relationship between materiality and mediation, considering such topics as the lived realities of network infrastructure. The contributors then highlight media technologies as always in motion, held together through the minute, unobserved work of many, including efforts to keep these technologies alive.ContributorsPablo J. Boczkowski, Geoffrey C. Bowker, Finn Brunton, Gabriella Coleman, Gregory J. Downey, Kirsten A. Foot, Tarleton Gillespie, Steven J. Jackson, Christopher M. Kelty, Leah A. Lievrouw, Sonia Livingstone, Ignacio Siles, Jonathan Sterne, Lucy Suchman, Fred Turner

Media Technologies: Essays on Communication, Materiality, and Society

Custodians of the Internet: Platforms, Content Moderation, and the Hidden Decisions That Shape Social Media

The flag is now a common mechanism for reporting offensive content to an online platform, and is used widely across most popular social media sites. It serves both as a solution to the problem of curating massive collections of user-generated content and as a rhetorical justification for platform owners when they decide to remove content. Flags are becoming a ubiquitous mechanism of governance—yet their meaning is anything but straightforward. In practice, the interactions between users, flags, algorithms, content moderators, and platforms are complex and highly strategic. Significantly, flags are asked to bear a great deal of weight, arbitrating both the relationship between users and platforms, and the negotiation around contentious public issues. In this essay, we unpack the working of the flag, consider alternatives that give greater emphasis to public deliberation, and consider the implications for online public discourse of this now commonplace yet rarely studied sociotechnical mechanism.

/pdf/what-is-a-flag-for-social-media-reporting-tools-and-the-h9hapncwj8.pdf

Tarleton Gillespie

Papers

The politics of ‘platforms’

The Relevance of Algorithms

Media Technologies: Essays on Communication, Materiality, and Society

Custodians of the Internet: Platforms, Content Moderation, and the Hidden Decisions That Shape Social Media

What is a flag for? Social media reporting tools and the vocabulary of complaint