T
Tatiana V. Novoselova
Researcher at Queen Mary University of London
Publications - 23
Citations - 695
Tatiana V. Novoselova is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Heat shock protein & Melanocortin. The author has an hindex of 11, co-authored 22 publications receiving 565 citations. Previous affiliations of Tatiana V. Novoselova include UCL Institute of Ophthalmology & Russian Academy of Sciences.
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Journal ArticleDOI
Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity.
Masato Asai,Masato Asai,Shwetha Ramachandrappa,Maria Joachim,Yuan Shen,Rong Zhang,Nikhil Nuthalapati,Visali Ramanathan,David E. Strochlic,Peter R. Ferket,Kirsten Linhart,Caroline Ho,Tatiana V. Novoselova,Sumedha Garg,Martin Ridderstråle,Claude Marcus,Joel N. Hirschhorn,Joel N. Hirschhorn,Keogh Jm,Stephen O'Rahilly,Li F. Chan,Adrian J. L. Clark,I. Sadaf Farooqi,Joseph A. Majzoub +23 more
TL;DR: The physiological role of brain-expressed melanocortin 2 receptor accessory protein 2 (MRAP2) is investigated, and four rare, potentially pathogenic genetic variants in MRAP2 are found, suggesting that the gene may also contribute to body weight regulation in humans.
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Treatment with extracellular HSP70/HSC70 protein can reduce polyglutamine toxicity and aggregation
Tatiana V. Novoselova,Boris A. Margulis,Sergey S. Novoselov,Alexander M. Sapozhnikov,Jacqueline van der Spuy,Michael E. Cheetham,Irina V. Guzhova +6 more
TL;DR: Preparations based on Heat Shock Protein 70 may have some potential as therapies for a variety of neurodegenerative pathologies, as well as on cultured cells and on animals.
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Whole-Exome Sequencing in the Differential Diagnosis of Primary Adrenal Insufficiency in Children
TL;DR: In this paper, the results of whole-exome sequencing of 43 patients referred to us with a diagnosis of familial glucocorticoid deficiency (FGD) who were mutation negative for MC2R, MRAP, and STAR the most commonly mutated genes in FGD.
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Pathophysiology of melanocortin receptors and their accessory proteins.
TL;DR: This review provides an insight into recent advances in MCRs and MRAPs physiology, focusing on the disorders associated with their dysfunction.
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Melanocortin receptor accessory proteins in adrenal gland physiology and beyond.
TL;DR: The expression of MRAPs outside the adrenal gland is suggestive of a wider physiological purpose, beyond MC2R-mediated adrenal steroidogenesis, and raises the intriguing possibility of a CNS role for the MR APs.