Showing papers by "Tetsuya Ohtaki published in 2008"
TL;DR: Results suggest that hypothalamic GALP is likely involved in stimulating GnRH/LH release, and that the stimulatory effect of GALp on LH release is oestrogen‐dependent in female rats.
Abstract: Galanin-like peptide (GALP), a ligand for three types of galanin receptor, is reported to have a role in regulating luteinising hormone (LH) release in male rodents and primates, but its role in LH release in female rodents remains controversial. The present study was conducted to test whether GALP has a stimulatory role in regulating LH secretion in female rats. The effect of i.c.v. infusion of GALP (5 nmol) on pulsatile LH release was investigated in Wistar-Imamichi strain female rats, or lean and obese Zucker rats. In oestradiol-17beta (oestradiol)-primed ovariectomised (OVX) Wistar-Imamichi female rats, i.c.v. infusion of GALP caused a gradual increase in LH release for the first 1.5 h after the infusion followed by an increased LH pulse frequency during the next 1.5 h, resulting in a significant increase in the mean LH concentrations and baseline levels of LH pulses throughout the sampling period and in the frequency of LH pulses at the last half of the period compared to vehicle-treated controls. The stimulatory effect of GALP was oestrogen-dependent because the same GALP treatment did not affect LH release in OVX rats in the absence of oestradiol. In lean Zucker rats, LH pulses were found in oestradiol-primed OVX individuals and central GALP infusion increased mean LH concentrations in the last half of the period. By contrast, few LH pulses were found in oestradiol-primed OVX obese Zucker rats reportedly with lower hypothalamic GALP expression. Central GALP infusion caused an apparent but transient increase in LH release, resulting in the significant increase in all pulse parameters of LH pulses compared to vehicle-treated controls in the first half of the sampling period. These results suggest that hypothalamic GALP is likely involved in stimulating GnRH/LH release, and that the stimulatory effect of GALP on LH release is oestrogen-dependent in female rats.
16 citations
Patent•
06 Oct 2008
TL;DR: The authors concerne un derive of NMU presentant une activite anti-appetante elevee meme sous une forme d'administration courante comme une administration peripherique.
Abstract: L'invention concerne un nouvel anti-appetant. Elle concerne egalement un derive de NMU presentant une activite anti-appetante elevee meme sous une forme d'administration courante comme une administration peripherique. Elle concerne un derive de neuromedine U qui contient au moins 8 acides amines a l'extremite C-terminale d'une sequence d'acides amines de neuromedine U et dans lequel du methoxypolyethylene glycol est lie a un polypeptide compose de la meme ou de pratiquement la meme sequence d'acides amines que celle de la neuromedine U par l'intermediaire d'un lieur ayant une structure specifique.