Y
Yoshihisa Uenoyama
Researcher at Nagoya University
Publications - 124
Citations - 4586
Yoshihisa Uenoyama is an academic researcher from Nagoya University. The author has contributed to research in topics: Kisspeptin & Luteinizing hormone. The author has an hindex of 29, co-authored 111 publications receiving 3792 citations. Previous affiliations of Yoshihisa Uenoyama include Okayama University & Mitsubishi.
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Journal ArticleDOI
Involvement of anteroventral periventricular metastin/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female rats.
Sachika Adachi,Shunji Yamada,Yoshihiro Takatsu,Hisanori Matsui,Mika Kinoshita,Kenji Takase,Hitomi Sugiura,Tetsuya Ohtaki,Hirokazu Matsumoto,Yoshihisa Uenoyama,Hiroko Tsukamura,Hiroko Tsukamura,Kinji Inoue,Kei-ichiro Maeda +13 more
TL;DR: It is demonstrated that preoptic area (POA) infusion of the anti-rat metastin/kisspeptin monoclonal antibody blocked the estrogen-induced LH surge, indicating that endogenous metastIn/kissPeptin released around the POA mediates the estrogen positive feedback effect on GnRH/LH release.
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Involvement of Central Metastin in the Regulation of Preovulatory Luteinizing Hormone Surge and Estrous Cyclicity in Female Rats
Mika Kinoshita,Hiroko Tsukamura,Sachika Adachi,Hisanori Matsui,Yoshihisa Uenoyama,Kinuyo Iwata,Shunji Yamada,Kinji Inoue,Tetsuya Ohtaki,Hirokazu Matsumoto,Kei-ichiro Maeda +10 more
TL;DR: Whether metastin, the product of metastasis suppressor gene KiSS-1, is a central neuropeptide regulating GnRH/LH surge and then estrous cyclicity in the female rat is examined.
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Gonadotrophin‐Releasing Hormone Pulse Generator Activity in the Hypothalamus of the Goat
Satoshi Ohkura,Kenji Takase,Shuichi Matsuyama,Kazutaka Mogi,Toru Ichimaru,Y. Wakabayashi,Yoshihisa Uenoyama,Yuji Mori,Robert A. Steiner,Hiroko Tsukamura,Kei-ichiro Maeda,Hiroaki Okamura +11 more
TL;DR: Observations suggest that the kisspeptin neurones in the ARC may be the intrinsic source of the GnRH pulse generator, and could plausibly reflect the pacemaker activity of kisspe leptin neurones, whose projections reach the median eminence where GnRH fibres project.
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Neurobiological mechanisms underlying GnRH pulse generation by the hypothalamus
Kei-ichiro Maeda,Satoshi Ohkura,Yoshihisa Uenoyama,Yoshihiro Wakabayashi,Yoshitaka Oka,Hiroko Tsukamura,Hiroaki Okamura +6 more
TL;DR: The present article provides a brief historical background to the work that led to the concept of the GnRH pulse generator, and proposes that kisspeptin neurons in the arcuate nucleus are key players in this regard.
Journal ArticleDOI
Inhibition of metastin (kisspeptin-54)-GPR54 signaling in the arcuate nucleus-median eminence region during lactation in rats.
Shunji Yamada,Yoshihisa Uenoyama,Mika Kinoshita,Kinuyo Iwata,Kenji Takase,Hisanori Matsui,Sachika Adachi,Kinji Inoue,Kei-ichiro Maeda,Hiroko Tsukamura,Hiroko Tsukamura +10 more
TL;DR: It is demonstrated that KiSS-1 mRNA/metastin (kisspeptin-54) expression is inhibited in the ARC by the suckling stimulus, suggesting that the inhibition is most probably involved in suppressing LH secretion in lactating rats.