Tetsuya Ohtaki

TL;DR: The optimization studies of metastin derivatives led to the discovery of 1, which suppressed plasma testosterone in rats at lower doses than those of leuprolide, and substitution with cyclic amino acids, which could change peptide conformation, retained its potency.

TL;DR: Autoradiographic studies showed that ETA receptors are most abundant in the cardiac muscle, intestine, large bowel, spleen, and testis.

TL;DR: Galanin receptor proteins, production and use thereof including screening of galanin receptor agonists and antagonists are provided in this article, where it is allowable to efficiently screen a Galin receptor receptor agonist or antagonist by using the Galin-RBP protein, the partial peptide thereof, the galin receptor protein encoding DNA, the receptor protein-containing cell or its membrane fraction.

TL;DR: The results suggest that 15 (NMU-0002), which showed potent and long-lasting biological profiles in vivo, represents a candidate peptide for investigating the central and peripheral actions of NMU and its potential for clinical use.

TL;DR: In this article, a stable metastin derivative having excellent biological activities (i.e., a cancer metastasis-inhibiting activity, a cancer proliferation-and a gonadotropin secretion-promoting activity, and a sex hormone secretion-enhancing activity) was proposed.