T
Tetsuya Ohtaki
Researcher at Takeda Pharmaceutical Company
Publications - 122
Citations - 6899
Tetsuya Ohtaki is an academic researcher from Takeda Pharmaceutical Company. The author has contributed to research in topics: Receptor & Peptide. The author has an hindex of 33, co-authored 122 publications receiving 6454 citations.
Papers
More filters
Journal ArticleDOI
Solubilization of receptor for pituitary adenylate cyclase activating polypeptide from bovine brain.
TL;DR: A receptor for pituitary adenylate cyclase activating polypeptide (PACAP) was solubilized from bovine brain membranes with 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate and retained a specificity for PACAP.
Journal ArticleDOI
Oestrogen-dependent stimulation of luteinising hormone release by galanin-like peptide in female rats.
Yoshihisa Uenoyama,Hiroko Tsukamura,Hiroko Tsukamura,Mika Kinoshita,Shunji Yamada,Kinuyo Iwata,Vutha Pheng,Somchai Sajapitak,Mototsugu Sakakibara,Tetsuya Ohtaki,Hirokazu Matsumoto,Kei-ichiro Maeda +11 more
TL;DR: Results suggest that hypothalamic GALP is likely involved in stimulating GnRH/LH release, and that the stimulatory effect of GALp on LH release is oestrogen‐dependent in female rats.
Patent
Novel protein, dna thereof and process for producing the same
TL;DR: A novel protein containing a peptide having a ligand activity to a G protein-coupled receptor protein; amides, esters, salts, etc. containing the same.
Patent
Isolated physiologically active peptide and use thereof
Tetsuya Ohtaki,Yasushi Masuda,Yoshihiro Takatsu,Takuya Watanabe,Yasuko Terao,Yasushi Shintani,Syuji Hinuma +6 more
TL;DR: In this article, a peptide and a DNA encoding the same are used as a reagent for screening a compound or its salt that promotes or inhibits the activity of the protein of the invention.
Journal ArticleDOI
Chemical synthesis and biological activity of the EGF‐like domain of heparin‐binding epidermal growth factor‐like growth factor (HB‐EGF)
TL;DR: Compared with h- EGF, the EGF-like domain of human HB-EGF showed a comparable mitogenic activity in the proliferation of NIH/3T3 fibroblast cells, suggesting that the E GF-likedomain of humanHB-EGf may play an important role in mitogenic activities.