T
Tetsuya Oshikawa
Researcher at University of Tokushima
Publications - 28
Citations - 836
Tetsuya Oshikawa is an academic researcher from University of Tokushima. The author has contributed to research in topics: Cytokine & Interleukin. The author has an hindex of 17, co-authored 28 publications receiving 804 citations. Previous affiliations of Tetsuya Oshikawa include National University of Colombia & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Expression of Toll-Like Receptor 4 on Dendritic Cells Is Significant for Anticancer Effect of Dendritic Cell-Based Immunotherapy in Combination with an Active Component of OK-432, a Streptococcal Preparation
Masato Okamoto,Sachiko Furuichi,Yasuhiko Nishioka,Tetsuya Oshikawa,Tomoyuki Tano,Sharif Uddin Ahmed,Kiyoshi Takeda,Shizuo Akira,Yoshiki Ryoma,Yoichiro Moriya,Motoo Saito,Saburo Sone,Mitsunobu Sato +12 more
TL;DR: It is suggested that OK-PSA may be a potent adjuvant for local DC therapy, and that DC therapy followed by OK- PSA is able to elicit anticancer activity even in aTLR4-deficient host when TLR4 is expressed only in DCs injected intratumorally.
Journal ArticleDOI
Involvement of Toll-Like Receptor 4 Signaling in Interferon-γ Production and Antitumor Effect by Streptococcal Agent OK-432
Masato Okamoto,Tetsuya Oshikawa,Tomoyuki Tano,Go Ohe,Sachiko Furuichi,Hidetomo Nishikawa,Sharif Uddin Ahmed,Sachiko Akashi,Kensuke Miyake,Osamu Takeuchi,Shizuo Akira,Yoichiro Moriya,Shuzo Matsubara,Yoshiki Ryoma,Motoo Saito,Mitsunobu Sato +15 more
TL;DR: TLR4 and MD-2 may mediate OK-432-induced anticancer immunity and be associated with the in vivo IFN-gamma induction in 19 patients administeredOK-432.
Journal ArticleDOI
Biyouyanagin A, an anti-HIV agent from Hypericum chinense L. var. salicifolium
Naonobu Tanaka,Mamoru Okasaka,Youko Ishimaru,Yoshihisa Takaishi,Mitsunobu Sato,Masato Okamoto,Tetsuya Oshikawa,Sharif Uddin Ahmed,L. Mark Consentino,Kuo‐Hsiung Lee +9 more
TL;DR: A structurally unique hydrophobic compound was isolated from the MeOH extract of the leaves of Hypericum chinense L. var.
Journal ArticleDOI
Mechanism of anticancer host response induced by OK-432, a streptococcal preparation, mediated by phagocytosis and Toll-like receptor 4 signaling.
Masato Okamoto,Tetsuya Oshikawa,Tomoyuki Tano,Sharif Uddin Ahmed,Shin Kan,Akiko Sasai,Sachiko Akashi,Kensuke Miyake,Yoichiro Moriya,Yoshiki Ryoma,Motoo Saito,Mitsunobu Sato +11 more
TL;DR: In in vivo experiments, the anticancer effect of OK-432 was significantly inhibited by suppression of phagocytosis activity by cytochalasin B, and in vitro experiments elucidated the mechanism mediated by phagocytes and TLR4 signaling in the immune effect ofOK-432.
Journal ArticleDOI
Mechanism for bone invasion of oral cancer cells mediated by interleukin‐6 in vitro and in vivo
Masato Okamoto,Kenji Hiura,Go Ohe,Yasuo Ohba,Kunihoro Terai,Tetsuya Oshikawa,Sachiko Furuichi,Hidetomo Nishikawa,Keiji Moriyama,Hideo Yoshida,Mitsunobu Sato +10 more
TL;DR: Although interleukin (IL)‐6 accelerates osteoclastic bone resorption, it remains unclear whether IL‐6 may be involved in bone invasion of oral cancer.