T
Teun van Gelder
Researcher at Erasmus University Medical Center
Publications - 46
Citations - 3102
Teun van Gelder is an academic researcher from Erasmus University Medical Center. The author has contributed to research in topics: Population & Tacrolimus. The author has an hindex of 25, co-authored 46 publications receiving 2738 citations. Previous affiliations of Teun van Gelder include Erasmus University Rotterdam.
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Journal ArticleDOI
Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR‐1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus
Dennis A. Hesselink,Ron H.N. van Schaik,Ilse P. van der Heiden,Marloes van der Werf,Peter J. H. Smak Gregoor,Jan Lindemans,Willem Weimar,Teun van Gelder +7 more
TL;DR: The calcineurin inhibitors cyclosporine (INN, ciclosporin) and tacrolimus have a narrow therapeutic index and show considerable interindividual variability in their pharmacokinetics.
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A New Functional CYP3A4 Intron 6 Polymorphism Significantly Affects Tacrolimus Pharmacokinetics in Kidney Transplant Recipients
Laure Elens,Rachida Bouamar,Dennis A. Hesselink,Vincent Haufroid,Ilse P. van der Heiden,Teun van Gelder,Ron H.N. van Schaik +6 more
TL;DR: The CYP3A4 rs35599367C>T polymorphism is associated with a significantly altered Tac metabolism and therefore increases the risk of supratherapeutic Tac concentrations early after transplantation.
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The Role of Pharmacogenetics in the Disposition of and Response to Tacrolimus in Solid Organ Transplantation
TL;DR: A randomised controlled study in kidney transplant recipients has demonstrated that a CYP3A5 genotype-based approach to tacrolimus dosing leads to more patients reaching the target concentration early after transplantation, but no improvement of clinical outcomes was observed, which may have been the result of the design of this particular study.
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CYP3A4*22: promising newly identified CYP3A4 variant allele for personalizing pharmacotherapy.
Laure Elens,Teun van Gelder,Dennis A. Hesselink,Vincent Haufroid,Vincent Haufroid,Ron H.N. van Schaik +5 more
TL;DR: The current literature on phenotypes linked to this new promising CYP3A4 genetic marker SNP with a frequency of 5-7% in the Caucasian population is summarized and the potential clinical relevance is discussed.
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Turning Off Frequently Overridden Drug Alerts: Limited Opportunities for Doing It Safely
TL;DR: Turning off DDI alerts hospital-wide appeared to be problematic because of differences among physicians regarding drug-related knowledge and of differences across the hospital in routine drug monitoring practices.