T
Thai-Son Tran
Researcher at Ho Chi Minh City Medicine and Pharmacy University
Publications - 6
Citations - 59
Thai-Son Tran is an academic researcher from Ho Chi Minh City Medicine and Pharmacy University. The author has contributed to research in topics: Acetylcholinesterase & Chemistry. The author has an hindex of 4, co-authored 5 publications receiving 25 citations.
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Journal ArticleDOI
Design of Curcumin and Flavonoid Derivatives with Acetylcholinesterase and Beta-Secretase Inhibitory Activities Using in Silico Approaches.
TL;DR: The study indicated that, by using in silico methods, a series of curcumin and flavonoid structures were generated with promising predicted bioactivities, which could be potential candidates for further research and lead optimization.
Journal ArticleDOI
Synthesis, In Silico and In Vitro Evaluation of Some Flavone Derivatives for Acetylcholinesterase and BACE-1 Inhibitory Activity
Thai-Son Tran,Thanh-Dao Tran,The-Huan Tran,Thanh-Tan Mai,Ngoc-Le Nguyen,Khac-Minh Thai,Minh-Tri Le,Minh-Tri Le +7 more
TL;DR: These molecules could be employed for further studies to discover new structures with dual action on both AChE and BACE-1 that could serve as novel therapies for AD.
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Three- and four-class classification models for P-glycoprotein inhibitors using counter-propagation neural networks.
TL;DR: Three and four-class classification models helped provide more information about the bioactivities of compounds not only on one target (P-gp), but also on a combination of multiple targets ( P-gp, CYP 3A), as well as improving therapeutic efficacy of commonly used cytotoxic drugs.
Journal ArticleDOI
Synthesis, In Silico and In Vitro Evaluation for Acetylcholinesterase and BACE-1 Inhibitory Activity of Some N-Substituted-4-Phenothiazine-Chalcones.
Thai-Son Tran,Minh-Tri Le,Minh-Tri Le,Thi-Cam-Vi Nguyen,The-Huan Tran,Thanh-Dao Tran,Khac-Minh Thai +6 more
TL;DR: The present study results suggested that, by using a combination of two types of predictive models, 2D-QSAR and molecular docking, it was possible to estimate the biological activities of the prepared compounds with relatively high accuracy.