Theodore Peters

TL;DR: Spectral and titrimetric data are reported which suggest that the Cu(II)-binding site for both albumin and peptide is a chelate locus involving multiple nitrogenous ligands in the neutral pH range, and that a histidyl residue occupies position 3 in the peptide chain.

TL;DR: The agreement between the results obtained with these independent techniques adds some confidence to the use of the [14C]leucine method and is suggested that the stimulus for increased secretion is a small increase in the quantity of albumin in the microsomal particles.

TL;DR: The amount of albumin in the intracellular albumin pool was observed to reach its normal level even before the circulating albumin level was restored, signifying that hypoalbuminemia can elicit increased synthesis without maintaining a decrease in the intrahepatic pool.