T
Theresa W. Depinet
Researcher at Case Western Reserve University
Publications - 5
Citations - 507
Theresa W. Depinet is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Breakpoint & Chromosome. The author has an hindex of 4, co-authored 5 publications receiving 495 citations.
Papers
More filters
Journal ArticleDOI
Chromosome breakage in the Prader-Willi and Angelman syndromes involves recombination between large, transcribed repeats at proximal and distal breakpoints.
James M. Amos-Landgraf,Yonggang Ji,Wayne Gottlieb,Theresa W. Depinet,Amy E. Wandstrat,Suzanne B. Cassidy,Daniel J. Driscoll,Peter K. Rogan,Stuart Schwartz,Robert D. Nicholls +9 more
TL;DR: It is postulate that the END repeats flanking 15q11-q13 mediate homologous recombination resulting in deletion and proposed that active transcription of these repeats in male and female germ cells may facilitate the homologously recombination process.
Journal ArticleDOI
Characterization of Neo-Centromeres in Marker Chromosomes Lacking Detectable Alpha-satellite DNA
Theresa W. Depinet,Joleen L. Zackowski,William C. Earnshaw,Sara Kaffe,Gurbax S. Sekhon,Richard Stallard,Beth A. Sullivan,Gail H. Vance,Daniel L. Van Dyke,Huntington F. Willard,Arthur B. Zinn,Stuart Schwartz +11 more
TL;DR: Eight accessory marker chromosomes in which fluorescence in-situ hybridization could detect neither pancentromeric nor chromosome-specific alpha-satellite DNA are studied, providing insight into a newly defined class of marker chromosomes that lack detectable alpha-Satellite DNA.
Journal ArticleDOI
Molecular characterization and delineation of subtle deletions in de novo "balanced" chromosomal rearrangements
Arun Kumar,L A Becker,Theresa W. Depinet,J M Haren,C L Kurtz,Nathaniel H. Robin,Suzanne B. Cassidy,D. J. Wolff,Stuart Schwartz +8 more
TL;DR: It is suggested that a systematic molecular study of breakpoints should be carried out in cases with apparently balanced chromosomal rearrangements and phenotypic abnormalities, because cryptic deletions near the breakpoints may explain the phenotypesic abnormalities in these cases.
Journal ArticleDOI
Molecular cytogenetic studies of a serially transplanted primary prostatic carcinoma xenograft (CWR22) and four relapsed tumors
Mary Kochera,Theresa W. Depinet,Theresa P. Pretlow,Joseph M. Giaconia,Nancy L. Edgehouse,Thomas G. Pretlow,Stuart Schwartz +6 more
TL;DR: CWR22 and CWR22‐R are xenografts that are unique in offering one strongly androgen‐dependent and several relapsed strains of a human prostate cancer that can be investigated in the laboratory.
Journal ArticleDOI
Molecular refinement of karyotype: beyond the cytogenetic band.
D. Alexa Sirko-Osadsa,Suzanne B. Cassidy,Theresa W. Depinet,Nathaniel H. Robin,Chanin Limwonge,Stuart Schwartz +5 more
TL;DR: Molecular characterization of subtle chromosomal aberrations can provide information to assist in predicting clinical outcome in cases involving genes known to have an effect due to haploinsufficiency or aberrant gene dosage.