T
Therese Catin
Publications - 3
Citations - 315
Therese Catin is an academic researcher. The author has contributed to research in topics: Debrisoquine & Mephenytoin. The author has an hindex of 3, co-authored 3 publications receiving 314 citations.
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High-performance liquid chromatographic assays for bufuralol 1′-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver
TL;DR: Assays for the in vitro metabolism of (+)- and (-)-bufuralol, debrisoquine, and dextromethorphan in human liver microsomes and reconstituted purified cytochrome P-450 isozymes indicate the involvement of the same enzyme in the metabolism of all three substrates investigated.
Journal ArticleDOI
Mephenytoin-type polymorphism of drug oxidation: purification and characterization of a human liver cytochrome P-450 isozyme catalyzing microsomal mephenytoin hydroxylation.
TL;DR: P-450 meph is the target of the genetic deficiency of mephenytoin and the concept that a functionally altered variant form of P- 450 meph causes this polymorphism is supported.