T
Thierry Besson
Researcher at Centre national de la recherche scientifique
Publications - 215
Citations - 3925
Thierry Besson is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Ring (chemistry) & Quinazoline. The author has an hindex of 37, co-authored 206 publications receiving 3551 citations. Previous affiliations of Thierry Besson include University of Orléans & Institut national des sciences appliquées.
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Microwave acceleration of the Pechmann reaction on graphite/montmorillonite K10: application to the preparation of 4-substituted 7-aminocoumarins
TL;DR: In this paper, the Pechmann reaction was performed via microwave irradiation of the reactants on solid support (graphite/montmorillonite K10) for the synthesis of 7-aminocoumarins.
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A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro.
Séverine Coutadeur,Hélène Benyamine,Laurence Delalonde,Catherine De Oliveira,Bertrand Leblond,Alicia Foucourt,Thierry Besson,Anne-Sophie Casagrande,Thierry Taverne,Angélique Girard,Matthew P. Pando,Laurent Desire +11 more
TL;DR: EHT 5372 is described, a novel, highly potent DYRK1A inhibitor with a high degree of selectivity over 339 kinases, which is thus as a key element of Aβ‐mediated Tau hyperphosphorylation, which links Tau and amyloid pathologies.
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Synthesis of novel 5-substituted indirubins as protein kinases inhibitors.
Anne Beauchard,Yoan Ferandin,Stéphane Frère,Olivier Lozach,Mélina Blairvacq,Laurent Meijer,Valérie Thiéry,Thierry Besson +7 more
TL;DR: In an effort to identify new pharmacological inhibitors of disease-relevant protein kinases with increased potency and selectivity, new 5-substituted indirubin derivatives were synthesized and evaluated.
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Microwave-assisted synthesis of galacto-oligosaccharides from lactose with immobilized β-galactosidase from Kluyveromyces lactis
TL;DR: GOS selectivity (GOS synthesis/lactose hydrolysis ratio) increased when the water activity of the media was reduced, notably with a high initial lactose concentration but also by using co-solvents in the media.
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Microwave-assisted Niementowski reaction. Back to the roots
TL;DR: In this article, the Niementowski synthesis of the 3H-quinazolin-4-one core was reinvestigated using microwave irradiation, and the experimental methodology and microwave conditions described here are well established, allowing significant rate enhancements and good yields compared to conventional reaction conditions.