Thomas B. Farb

TL;DR: These studies characterize the insulinotropic effects of an early-stage, small molecule GLP-1 receptor agonist and provide compelling evidence to support pharmaceutical optimization.

TL;DR: The data suggest that, in lean mice, 2-OG and LEA may serve as physiologically relevant endogenous GPR119 agonists that mediate receptor activation upon nutrient uptake.

TL;DR: It is demonstrated that small molecules targeting the GLP-1 receptor can increase binding and receptor activation of the endogenous peptide oxyntomodulin, and the biased signaling engendered by BETP suggests that GLF1 receptor mobilization of cAMP is the critical insulinotropic signaling event.

TL;DR: It is concluded that hypusination by DHS is required for the ongoing production of proteins, particularly CHOP, in response to ER stress in the β cell.

TL;DR: This work provides the first comprehensive characterization of a novel polyclonal antibody (IU-88) that specifically recognizes the hypusinated eIF5A, the only protein known to contain the amino acid hypusine, which is formed posttranslationally.