Thomas E. Blue

TL;DR: Critical issues that must be addressed include the need for more selective and effective boron delivery agents, the development of methods to provide semiquantitative estimates of tumor borons content before treatment, improvements in clinical implementation of BNCT, and a need for randomized clinical trials with an unequivocal demonstration of therapeutic efficacy.

TL;DR: In this article, the development of low-energy light ion accelerator-based neutron sources (ABNSs) for the treatment of brain tumors through an intact scalp and skull using boron neutron capture therapy (BNCT).

TL;DR: These data convincingly show the therapeutic efficacy of molecular targeting of EGFR using a boronated mAb either alone or in combination with BPA and provide a platform for the future development of combinations of high and low molecular weight delivery agents for BNCT of brain tumors.

TL;DR: In this paper, a neutronic study of an accelerator-based neutron irradiation facility (ANIF) for boron neutron capture therapy (BNCT) was performed using three-dimensional Monte Carlo transport calculations.

TL;DR: In this article, the effects of high energy neutron irradiation on the deep level defect concentration profile throughout the bandgap of β-Ga2O3 were investigated by a combination of DLOS and deep level transient spectroscopy (DLTS), with no discernable impact on traps within ∼1 eV of the conduction band edge.