T
Thomas Gerken
Researcher at University of Oxford
Publications - 4
Citations - 1692
Thomas Gerken is an academic researcher from University of Oxford. The author has contributed to research in topics: FTO gene & Alpha-Ketoglutarate-Dependent Dioxygenase FTO. The author has an hindex of 3, co-authored 4 publications receiving 1545 citations.
Papers
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Journal ArticleDOI
The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate–Dependent Nucleic Acid Demethylase
Thomas Gerken,Christophe Girard,Yi-Chun Loraine Tung,Celia J. Webby,Vladimir Saudek,Kirsty S. Hewitson,Giles S.H. Yeo,Michael A. McDonough,Sharon Cunliffe,Luke A. McNeill,Juris Galvanovskis,Patrik Rorsman,Peter Robins,Xavier Prieur,Anthony P. Coll,Marcella Ma,Zorica Jovanovic,I. Sadaf Farooqi,Barbara Sedgwick,Inês Barroso,Tomas Lindahl,Chris P. Ponting,Frances M. Ashcroft,Stephen O'Rahilly,Christopher J. Schofield +24 more
TL;DR: It is found that recombinant murine Fto catalyzes the Fe(II)- and 2OG-dependent demethylation of 3-methylthymine in single-stranded DNA, with concomitant production of succinate, formaldehyde, and carbon dioxide.
Journal ArticleDOI
A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene.
Chris Church,Sheena Lee,Eleanor A.L. Bagg,James S. McTaggart,Robert M. J. Deacon,Thomas Gerken,Angela Lee,Lee Moir,Jasmin Mecinović,Mohamed M. Quwailid,Christopher J. Schofield,Frances M. Ashcroft,Roger D. Cox +12 more
TL;DR: It is shown that a dominant point mutation in the mouse Fto gene results in reduced fat mass, increased energy expenditure, and unchanged physical activity, providing direct functional evidence that FTO is a causal gene underlying obesity.
Patent
Method for assaying FTO (2-oxoglutarate dependent oxygenase) activity
TL;DR: In this article, a method for assaying oxygenase activity, the method comprising monitoring oxygenase activation of FTO, is presented. But this method is not suitable for the measurement of oxygenase enzymes.
Patent
Procédé d'analyse de l'activité (oxygénase 2-oxoglutarate dépendante) de la fto
TL;DR: In this article, the authors propose a procede qui permet d'analyser une activite oxygenase, lequel procede consiste a surveiller l'activite oxygenases de la FTO.