C
Christophe Girard
Researcher at French Institute of Health and Medical Research
Publications - 39
Citations - 4712
Christophe Girard is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Kir6.2 & Melanoma. The author has an hindex of 25, co-authored 37 publications receiving 4263 citations. Previous affiliations of Christophe Girard include Centre national de la recherche scientifique & University of Oxford.
Papers
More filters
Journal ArticleDOI
The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate–Dependent Nucleic Acid Demethylase
Thomas Gerken,Christophe Girard,Yi-Chun Loraine Tung,Celia J. Webby,Vladimir Saudek,Kirsty S. Hewitson,Giles S.H. Yeo,Michael A. McDonough,Sharon Cunliffe,Luke A. McNeill,Juris Galvanovskis,Patrik Rorsman,Peter Robins,Xavier Prieur,Anthony P. Coll,Marcella Ma,Zorica Jovanovic,I. Sadaf Farooqi,Barbara Sedgwick,Inês Barroso,Tomas Lindahl,Chris P. Ponting,Frances M. Ashcroft,Stephen O'Rahilly,Christopher J. Schofield +24 more
TL;DR: It is found that recombinant murine Fto catalyzes the Fe(II)- and 2OG-dependent demethylation of 3-methylthymine in single-stranded DNA, with concomitant production of succinate, formaldehyde, and carbon dioxide.
Journal ArticleDOI
Overexpression of Fto leads to increased food intake and results in obesity.
Chris Church,Lee Moir,Fiona McMurray,Christophe Girard,Gareth Banks,Lydia Teboul,Sara Wells,Jens C. Brüning,Patrick M. Nolan,Frances M. Ashcroft,Roger D. Cox +10 more
TL;DR: This study provides the first direct evidence that increased Fto expression causes obesity in mice and shows here that ubiquitous overexpression of Fto leads to a dose-dependent increase in body and fat mass, irrespective of whether mice are fed a standard or a high-fat diet.
Journal ArticleDOI
Control of Pancreatic β Cell Regeneration by Glucose Metabolism
Shay Porat,Noa Weinberg-Corem,Sharona Tornovsky-Babaey,Rachel Schyr-Ben-Haroush,Ayat Hija,Miri Stolovich-Rain,Daniela Dadon,Zvi Granot,Vered Ben-Hur,Peter White,Christophe Girard,Rotem Karni,Klaus H. Kaestner,Frances M. Ashcroft,Mark A. Magnuson,Ann Saada,Joseph Grimsby,Benjamin Glaser,Yuval Dor +18 more
TL;DR: Intracellularly, genetic and pharmacologic manipulations reveal that glucose induces β cell replication via metabolism by glucokinase, the first step of glycolysis, followed by closure of K(ATP) channels and membrane depolarization, providing a molecular mechanism for homeostatic control of β cell mass by metabolic demand.
Journal ArticleDOI
Permanent neonatal diabetes caused by dominant, recessive, or compound heterozygous SUR1 mutations with opposite functional effects.
Sian Ellard,Sarah E. Flanagan,Christophe Girard,Ann-Marie Patch,Lorna W. Harries,Andrew Parrish,Emma L. Edghill,Deborah J G Mackay,Peter Proks,Kenju Shimomura,Holger Haberland,Dennis Carson,Julian P.H. Shield,Andrew T. Hattersley,Frances M. Ashcroft +14 more
TL;DR: A novel mutational mechanism was observed in which a heterozygous activating mutation resulted in PNDM only when a second, loss-of-function mutation was also present, and functional studies of selected mutations showed a reduced response to ATP consistent with an activating mutation that results in reduced insulin secretion.
Journal ArticleDOI
A heterozygous activating mutation in the sulphonylurea receptor SUR1 (ABCC8) causes neonatal diabetes
Peter Proks,Amanda L. Arnold,Jan Bruining,Christophe Girard,Sarah E. Flanagan,Brian Larkin,Kevin Colclough,Andrew T. Hattersley,Frances M. Ashcroft,Sian Ellard +9 more
TL;DR: It is demonstrated that SUR1 mutations constitute a new genetic aetiology for neonatal diabetes and that they act by reducing the K(ATP) channel's ATP sensitivity.