T
Thomas Hachenberg
Researcher at Otto-von-Guericke University Magdeburg
Publications - 127
Citations - 2756
Thomas Hachenberg is an academic researcher from Otto-von-Guericke University Magdeburg. The author has contributed to research in topics: Mechanical ventilation & Medicine. The author has an hindex of 25, co-authored 116 publications receiving 2457 citations.
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Journal ArticleDOI
Induction of P‐glycoprotein by rifampin increases intestinal secretion of talinolol in human beings: A new type of drug/drug interaction
Kristin Westphal,Anita Weinbrenner,Zschiesche M,G. Franke,Manfred Knoke,Reinhard Oertel,Peter Fritz,Oliver von Richter,Rolf Warzok,Thomas Hachenberg,Hans-Martin Kauffmann,Dieter Schrenk,Bernd Terhaag,Heyo K. Kroemer,Werner Siegmund +14 more
TL;DR: It is hypothesized that rifampin affects pharmacokinetics of the P‐glycoprotein substrate talinolol, a β1‐blocker without appreciable metabolic disposition but intense intestinal secretion in human beings.
Journal ArticleDOI
The pulmonary immune effects of mechanical ventilation in patients undergoing thoracic surgery.
Thomas F. Schilling,Alf Kozian,Christof Huth,Frank Bühling,Moritz Kretzschmar,Tobias Welte,Thomas Hachenberg +6 more
TL;DR: Results indicate that MV may induce epithelial damage and a proinflammatory response in the ventilated lung and reduction of tidal volume during OLV may reduce alveolar concentrations of TNF-&agr; and of sICAM-1.
Journal ArticleDOI
Atelectasis and Gas Exchange after Cardiac Surgery
TL;DR: Large atelectasis in the dorsal part of the lungs was found on the first postoperative day after cardiac surgery, however, there was no clear correlation between atElectasis and measured shunt fraction.
Journal ArticleDOI
Effects of Volatile and Intravenous Anesthesia on the Alveolar and Systemic Inflammatory Response in Thoracic Surgical Patients
Thomas F. Schilling,Alf Kozian,Mert Şentürk,Christof Huth,Annegret Reinhold,Göran Hedenstierna,Thomas Hachenberg +6 more
TL;DR: Both desflurane and sevoflurane suppress the local alveolar, but not the systemic, inflammatory responses to OLV and thoracic surgery.
Journal ArticleDOI
Effects of propofol and desflurane anaesthesia on the alveolar inflammatory response to one-lung ventilation
Thomas F. Schilling,Alf Kozian,Moritz Kretzschmar,Christof Huth,Tobias Welte,Frank Bühling,Göran Hedenstierna,Thomas Hachenberg +7 more
TL;DR: These data indicate that pro-inflammatory reactions during OLV were influenced by the type of general anaesthesia, and different patterns of alveolar cytokines may be a result of increased granulocyte recruitment during propofol anaesthesia.