Thomas Heuser

TL;DR: The results suggest that cholesterol metabolism is central to M. tuberculosis's unusual ability to survive in macrophages and provide insights into potential targets for novel therapeutics.

TL;DR: Elegant cryoelectron tomography reveals that the nexin link between microtubule doublets in 9 + 2 axonemal structures, critical for their ability to bend, is the dynein regulatory complex.

TL;DR: It is reported that HSV-1 NEC alone is sufficient for membrane budding in vitro and thus represents a complete membrane deformation and scission machinery and functions as minimal virus-encoded membrane-budding machinery during nuclear egress and does not require additional cellular factors.

TL;DR: Cryo-electron tomography of Chlamydomonas and sea urchin flagella is used to answer long-standing questions and provide information about the structure of axonemal doublet microtubules (DMTs) to provide a critical foundation for future work on the molecular assembly and stability of the axoneme, as well as its function in motility and sensory transduction.

TL;DR: Evidence is provided that irrespective of their cellular origin, EVs support the propagation of coagulation via the exposure of phosphatidylserine, while the expression of functional tissue factor on EVs appears to be limited to pathological conditions.