T
Thomas Horn
Researcher at Chiron Corporation
Publications - 37
Citations - 1427
Thomas Horn is an academic researcher from Chiron Corporation. The author has contributed to research in topics: Oligonucleotide & Polynucleotide. The author has an hindex of 12, co-authored 37 publications receiving 1427 citations. Previous affiliations of Thomas Horn include Siemens & Bayer Corporation.
Papers
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Patent
Polynucleotide reagents containing modified deoxyribose moieties and associated methods of synthesis and use
Michael S. Urdea,Thomas Horn +1 more
TL;DR: In this article, methods and reagents for synthesizing polynucleotides containing modified deoxyribose residues were provided for hybridization assay formats, which are useful in a variety of hybridization formats.
Patent
Multifunctional nucleic acid monomer
Michael S. Urdea,Thomas Horn +1 more
TL;DR: This paper introduced cleavable sites and/or abasic sites into oligonucleotide or polynucleotide chains, which are useful in a variety of biochemical and chemical contexts including nucleic hybridization assays and chemical phosphorylation of hydroxyl-containing compounds.
Patent
Nucleic acid hybridization assays employing large comb-type branched polynucleotides
TL;DR: Comb-type branched polynucleotides are used as amplification multimers in nucleic acid hybridization assays as discussed by the authors, where the polynomial is used as an amplification multimer.
Patent
Solution phase nucleic acid sandwich assay and polynucleotide probes useful therein
TL;DR: In this paper, two reagent sets are used to detect nucleic acid sequences. The first set is a labeling set consisting of an analyte complementary region and a first recognition sequence region, and the second set is capturing set comprising a second nucleic amino acid sequence probe and a specific binding pair member conjugated to a sequence complementary to the second recognition sequence.
Patent
Modified N-4 nucleotides for use in amplified nucleic acid hybridization assays
Michael S. Urdea,Thomas Horn +1 more
TL;DR: Linear or branched oligonucleotide multimers are useful as amplifiers in biochemical assays which comprise (1) at least one first single-stranded oligonotide unit that is complementary to a singlestranded sequence of interest, and (2) a multiplicity of second single strand-linked oligon nucleotide units that are complementary to the label of interest as discussed by the authors.