T
Thomas J. Braciale
Researcher at University of Virginia
Publications - 122
Citations - 9737
Thomas J. Braciale is an academic researcher from University of Virginia. The author has contributed to research in topics: Cytotoxic T cell & Immune system. The author has an hindex of 52, co-authored 118 publications receiving 9005 citations. Previous affiliations of Thomas J. Braciale include Carter Center & University of Virginia Health System.
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Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10
TL;DR: The results show that antiviral Teff cells exert regulatory functions—that is, they fine-tune the extent of lung inflammation and injury associated with influenza infection by producing an anti-inflammatory cytokine.
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Accelerated Migration of Respiratory Dendritic Cells to the Regional Lymph Nodes Is Limited to the Early Phase of Pulmonary Infection
TL;DR: It is demonstrated that the accelerated migration of RDC to the draining peribronchial lymph nodes occurs only during the first 24 hr after pulmonary virus infection, and RDC are refractory to further migration thereafter in spite of ongoing virus replication and pulmonary inflammation.
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Local-pooled-error test for identifying differentially expressed genes with a small number of replicated microarrays
TL;DR: The results show that the LPE method effectively identifies significant differential-expression patterns with a small number of replicated arrays, and is implemented with S-PLUS and R functions.
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Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation
David J. Kittlesen,Kimberly A. Chianese-Bullock,Zhi Qiang Yao,Thomas J. Braciale,Young S. Hahn +4 more
TL;DR: Investigation of the mechanism of HCV core-mediated immunosuppression searched for host proteins capable of associating with the core protein using a yeast two-hybrid system and identified a gene encoding the gC1q receptor, which is a ligand of C1qR and is involved in the early host defense against infection.
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The host immune response in respiratory virus infection: balancing virus clearance and immunopathology
TL;DR: The continuing threat posed by pandemic influenza as well as the emergence of novel respiratory viruses also capable of producing severe acute lung injury such as SARS- coV, MERS-CoV, and enterovirus D68 highlights the need for an understanding of the immune mechanisms that contribute to virus elimination and immune-mediated injury.