T
Thomas J. Rimele
Researcher at Research Triangle Park
Publications - 54
Citations - 2005
Thomas J. Rimele is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Agonist & Vascular smooth muscle. The author has an hindex of 20, co-authored 54 publications receiving 1959 citations. Previous affiliations of Thomas J. Rimele include Ohio State University & Mayo Clinic.
Papers
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Journal ArticleDOI
Respiratory epithelium inhibits bronchial smooth muscle tone
TL;DR: The results suggest that respiratory epithelial cells may generate an inhibitory signal to decrease the responsiveness of bronchial smooth muscle to contractile agonists and augment the effectiveness of inhibitory stimuli.
Journal ArticleDOI
BMY 7378 is a selective antagonist of the D subtype of α1-adrenoceptors
Aaron S. Goetz,Holly K. King,Stuart D.C. Ward,Timothy A. True,Thomas J. Rimele,David L. Saussy +5 more
TL;DR: BMY 7378 (8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8- azaspiro[4.5]decane-7,9-dione dihydrochloride), a 5-HT1A receptor partial agonist, also binds to alpha 1-adrenoceptors.
Journal Article
Interaction of neutrophils with vascular smooth muscle: identification of a neutrophil-derived relaxing factor.
Thomas J. Rimele,Robert J. Sturm,L.M. Adams,D. E. Henry,Richard J. Heaslip,B.M. Weichman,D. Grimes +6 more
TL;DR: Results demonstrate that rat neutrophils release a factor that has a pharmacologic profile similar to that previously reported for the relaxing factor released from the vascular endothelium.
Journal ArticleDOI
Discovery of 1,5-benzodiazepines with peripheral cholecystokinin (CCK-A) receptor agonist activity. 1. Optimization of the agonist "trigger"
Christopher Joseph Aquino,Armour Duncan Robert,Judd Berman,Larry S. Birkemo,Robin A. E. Carr,Dallas K. Croom,Milana Dezube,Robert W. Dougherty,Gregory N. Ervin,Mary K. Grizzle,Julie E. Head,Gavin C. Hirst,Michael K. James,Michael F. Johnson,Laurence J. Miller,Kennedy L. Queen,Thomas J. Rimele,David N. Smith,Elizabeth E. Sugg +18 more
TL;DR: Screening of compounds selected from the Glaxo registry file for contractile activity on the isolated guinea pig gallbladder identified a series of 1,5-benzodiazepines with peripheral cholecystokinin (CCK) receptor agonist activity that are equipotent to CCK as anorectic agents in rats following intraperitoneal administration.
Journal Article
Characterization of postjunctional alpha-1 and alpha-2 adrenoceptors activated by exogenous or nerve-released norepinephrine in the canine saphenous vein.
TL;DR: The results suggest that the alpha-1 and alpha-2 adrenoceptor-mediated concentration-effect curves to norepinephrine are almost coincident and that alpha- 2 adrenergic stimulation produces only partial activation of the vascular smooth muscle.