T
Thomas K. Darlington
Researcher at Scripps Research Institute
Publications - 26
Citations - 2123
Thomas K. Darlington is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Timeless & Medicine. The author has an hindex of 12, co-authored 19 publications receiving 1943 citations. Previous affiliations of Thomas K. Darlington include Howard Hughes Medical Institute & University of California, San Diego.
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Journal ArticleDOI
Closing the Circadian Loop: CLOCK-Induced Transcription of Its Own Inhibitors per and tim
Thomas K. Darlington,Thomas K. Darlington,Thomas K. Darlington,Karen Wager-Smith,Karen Wager-Smith,Karen Wager-Smith,M. Fernanda Ceriani,M. Fernanda Ceriani,M. Fernanda Ceriani,David Staknis,David Staknis,David Staknis,Nicholas Gekakis,Nicholas Gekakis,Nicholas Gekakis,Thomas D.L. Steeves,Thomas D.L. Steeves,Thomas D.L. Steeves,Charles J. Weitz,Charles J. Weitz,Charles J. Weitz,Joseph S. Takahashi,Steve A. Kay,Steve A. Kay,Steve A. Kay +24 more
TL;DR: The Drosophila CLOCK protein was shown to induce transcription of the circadian rhythm genes period and timeless, and PERIOD and TIMELESS proteins blocked dCLOCK's ability to transactivate their promoters via the E-box.
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Light-dependent sequestration of TIMELESS by CRYPTOCHROME.
M. Fernanda Ceriani,Thomas K. Darlington,David Staknis,Paloma Mas,Allegra A. Petti,Charles J. Weitz,Steve A. Kay +6 more
TL;DR: CRYPTOCHROME (CRY), a protein involved in circadian photoperception in Drosophila, is shown to block the function of PERIOD/TIMELESS (PER/Tim) heterodimeric complexes in a light-dependent fashion.
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Nanoparticle characteristics affecting environmental fate and transport through soil
TL;DR: Aluminum nanoparticles commonly are used in energetic formulations and may be released into the environment during their handling and use, but size, charge, and agglomeration rate of nanoparticles in the transport medium are predictive of nanoparticle mobility in soil.
Journal ArticleDOI
Multiple healing effect of thermally activated self-healing composites based on Diels–Alder reaction
Jong Se Park,Thomas K. Darlington,Anthony F. Starr,Kosuke Takahashi,Joseph Riendeau,H. Thomas Hahn +5 more
TL;DR: In this paper, self-healing composites using a thermally mendable polymer, bis-maleimide tetrafuran (2MEP4F), based on Diels-Alder reaction and electrical resistive heating were fabricated using a vacuum assisted injection molding method.
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The period E-box Is Sufficient to Drive Circadian Oscillation of Transcription In Vivo
TL;DR: In vivo, the same 18 bp E-box region generated rhythmic expression of luciferase in flies under both light-dark cycling and constant conditions, demonstrating in vivo that the known circadian genes that form the core of the circadian oscillator in Drosophila integrate their activities at a single DNA element.