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Paul E. Hardin
Researcher at Texas A&M University
Publications - 107
Citations - 12377
Paul E. Hardin is an academic researcher from Texas A&M University. The author has contributed to research in topics: Circadian clock & Circadian rhythm. The author has an hindex of 53, co-authored 105 publications receiving 11552 citations. Previous affiliations of Paul E. Hardin include University of Texas MD Anderson Cancer Center & Brandeis University.
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Journal ArticleDOI
Circadian rhythms from multiple oscillators: lessons from diverse organisms
Deborah Bell-Pedersen,Vincent M. Cassone,David J. Earnest,David J. Earnest,Susan S. Golden,Paul E. Hardin,Terry L. Thomas,Mark J. Zoran +7 more
TL;DR: Comparisons of circadian clocks in unicellular and multicellular organisms using molecular genetics and genomics have provided new insights into the mechanisms and complexity of clock systems.
Journal ArticleDOI
Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels
TL;DR: Observations indicate that the cycling of per-encoded protein could result from per RNA cycling, and that there is a feedback loop through which the activity of each per gene product causes cycling of its own RNA.
Journal ArticleDOI
vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock
Shawn A. Cyran,Anna M. Buchsbaum,Karen L. Reddy,Meng Chi Lin,Nicholas R J Glossop,Paul E. Hardin,Michael W. Young,Robert V. Storti,Justin Blau +8 more
TL;DR: It is shown here that VRI and PDP1 proteins feed back and directly regulate dClock expression, comprising a second feedback loop in the Drosophila clock that gives rhythmic expression of dClock, and probably of other genes, to generate accurate circadian rhythms.
Journal ArticleDOI
The circadian timekeeping system of Drosophila.
TL;DR: The intracellular feedback loops that form the core of the Drosophila circadian oscillator are described and it is considered how they are entrained by environmental light cycles, where they operate within the fly andHow they are thought to control overt rhythms in physiology and behavior.
Journal ArticleDOI
Interlocked feedback loops within the Drosophila circadian oscillator.
TL;DR: The results demonstrate that the Drosophila circadian feedback loop is composed of two interlocked negative feedback loops: a per-tim loop, which is activated by dCLK-CYC and repressed by PER-TIM, and a dClk loop,Which is repression by dClK- CYC and derepressed by PerIOD-tIM.