T
Thomas K. Hughes
Researcher at University of Texas Medical Branch
Publications - 83
Citations - 3663
Thomas K. Hughes is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Immune system & Receptor. The author has an hindex of 31, co-authored 83 publications receiving 3566 citations. Previous affiliations of Thomas K. Hughes include University of Texas at Austin & University of Texas System.
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Journal ArticleDOI
The interferons. Mechanisms of action and clinical applications.
Samuel Baron,Stephen K. Tyring,Fleischmann Wr,Dorian H. Coppenhaver,David W. Niesel,Gary R. Klimpel,G J Stanton,Thomas K. Hughes +7 more
TL;DR: The interferons (IFN) are one of the body's natural defensive responses to such foreign components as microbes, tumors, and antigens and future clinical uses of IFNs may emphasize combination therapy with other cytokines, chemotherapy, radiation, surgery, hyperthermia, or hormones.
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Opioid and Opiate Immunoregulatory Processes
George B. Stefano,Berta Scharrer,Eric M. Smith,Thomas K. Hughes,Harold I. Magazine,Thomas V. Bilfinger,Alan R. Hartman,Gregory L. Fricchione,Yu Liu,Maynard H. Makman +9 more
TL;DR: The present review provides an overview of recent advances in the field of opiate and opioid immunoregulatory processes and speculates as to their significance in diverse biological systems.
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Herpesvirus-like DNA sequences in non-Kaposi's sarcoma skin lesions of transplant patients
Stephen K. Tyring,Thomas K. Hughes,Peter L. Rady,Yen,Ida Orengo,J.L. Rollefson,Suzanne Bruce +6 more
TL;DR: The results suggest that KSHV is associated with lesions other than KS in non-AIDS immunocompromised patients, and may also be involved in the pathogenesis of the various forms of proliferative skin lesions from organ-transplant patients.
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Nested PCR with the PGMY09/11 and GP5(+)/6(+) primer sets improves detection of HPV DNA in cervical samples.
Andrea L. Fuessel Haws,Qin He,Peter L. Rady,Lifang Zhang,James J. Grady,Thomas K. Hughes,Kendra Stisser,Rolf König,Stephen K. Tyring,Stephen K. Tyring +9 more
TL;DR: In this comparative study, nested PCR using the novel PGMY/GP(+) primer set combination was found to be more type sensitive than the nested PCR with the MY/GP (+) primer sets, detecting a wider range of HPV types, low copy HPVs, and better characterizing samples infected with multiple strains of HPV.
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Malignant transformation of recurrent respiratory papillomatosis associated with integrated human papillomavirus type 11 DNA and mutation of p53.
TL;DR: Molecular genetic alterations occurring in a case of metastasizing SCC that arose in long‐standing bronchopulmonary papillomatosis indicated that the p53 genetic mutation was associated with integration of HPV‐11 in histologically malignant lesions, which may promote a progressive genetic instability that can lead to the development and clonal expansion of malign lesions in RRP.