T
Thomas Kane
Researcher at Moorfields Eye Hospital
Publications - 10
Citations - 201
Thomas Kane is an academic researcher from Moorfields Eye Hospital. The author has contributed to research in topics: Achromatopsia & Macular telangiectasia. The author has an hindex of 6, co-authored 9 publications receiving 132 citations. Previous affiliations of Thomas Kane include UCL Institute of Ophthalmology & University College London.
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Journal ArticleDOI
Prospective Cohort Study of Childhood-Onset Stargardt Disease: Fundus Autofluorescence Imaging, Progression, Comparison with Adult-Onset Disease, and Disease Symmetry.
Michalis Georgiou,Thomas Kane,Preena Tanna,Zaina Bouzia,Navjit Singh,Angelos Kalitzeos,Rupert W. Strauss,Kaoru Fujinami,Michel Michaelides,Michel Michaelides +9 more
TL;DR: DAF area quantification was highly reliable and may serve as a robust structural endpoint in childhood-onset disease, making this subtype of STGD1 ideally suited to be considered for prioritization in clinical trials.
Journal ArticleDOI
Adaptive Optics Retinal Imaging in CNGA3-Associated Achromatopsia: Retinal Characterization, Interocular Symmetry, and Intrafamilial Variability.
Michalis Georgiou,Michalis Georgiou,Katie M. Litts,Angelos Kalitzeos,Angelos Kalitzeos,Christopher S Langlo,Thomas Kane,Thomas Kane,Navjit Singh,Navjit Singh,Melissa Kassilian,Melissa Kassilian,Nashila Hirji,Nashila Hirji,Neruban Kumaran,Neruban Kumaran,Alfredo Dubra,Joseph Carroll,Michel Michaelides,Michel Michaelides +19 more
TL;DR: The remnant cone mosaics were irregular and variably disrupted, with significantly lower peak foveal cone density than unaffected individuals, and interocular symmetry suggests that both eyes have comparable therapeutic potential and the fellow eye can serve as a valid control.
Journal ArticleDOI
Deep Phenotyping of PDE6C-Associated Achromatopsia
Michalis Georgiou,Michalis Georgiou,Anthony G. Robson,Anthony G. Robson,Navjit Singh,Navjit Singh,Nikolas Pontikos,Nikolas Pontikos,Thomas Kane,Thomas Kane,Nashila Hirji,Nashila Hirji,Caterina Ripamonti,Tryfon Rotsos,Alfredo Dubra,Angelos Kalitzeos,Angelos Kalitzeos,Andrew R. Webster,Andrew R. Webster,Joseph Carroll,Michel Michaelides,Michel Michaelides +21 more
TL;DR: PDE6C retinopathy is a severe cone dysfunction syndrome often presenting as typical achromatopsia but without foveal hypoplasia, and myopia and slowly progressive maculopathy are common features.
Journal ArticleDOI
Characterization of Retinal Structure in ATF6-Associated Achromatopsia.
Rebecca R. Mastey,Michalis Georgiou,Michalis Georgiou,Christopher S Langlo,Angelos Kalitzeos,Angelos Kalitzeos,Emily J Patterson,Thomas Kane,Thomas Kane,Navjit Singh,Navjit Singh,Ajoy Vincent,Anthony T. Moore,Stephen H. Tsang,Jonathan H. Lin,Marielle P. Young,M. Elizabeth Hartnett,Elise Heon,Susanne Kohl,Michel Michaelides,Michel Michaelides,Joseph Carroll +21 more
TL;DR: A near absence of cone structure is demonstrated in subjects harboring ATF6 mutations, which implicates ATF6 as having a major role in cone development and suggests that at least a subset of subjects with ATF6-ACHM have markedly fewer cellular targets for cone-directed gene therapies than do subjects with CNGA3- or CNGB3-ACHm.
Journal ArticleDOI
Photoreceptor Structure in GNAT2-Associated Achromatopsia.
Michalis Georgiou,Michalis Georgiou,Navjit Singh,Navjit Singh,Thomas Kane,Thomas Kane,Anthony G. Robson,Anthony G. Robson,Angelos Kalitzeos,Angelos Kalitzeos,Nashila Hirji,Nashila Hirji,Andrew R. Webster,Andrew R. Webster,Alfredo Dubra,Joseph Carroll,Michel Michaelides,Michel Michaelides +17 more
TL;DR: The cone mosaic in GNAT2-ACHM is relatively well preserved, potentially allowing for a wide therapeutic window for cone-directed interventions.