T
Thomas Ludwig
Researcher at University of Münster
Publications - 9
Citations - 445
Thomas Ludwig is an academic researcher from University of Münster. The author has contributed to research in topics: Cisplatin & Cell culture. The author has an hindex of 7, co-authored 9 publications receiving 422 citations. Previous affiliations of Thomas Ludwig include Leiden University.
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Journal ArticleDOI
Nephrotoxicity of platinum complexes is related to basolateral organic cation transport
Thomas Ludwig,Christoph Riethmüller,Christoph Riethmüller,Michael Gekle,Michael Gekle,Gerald Schwerdt,Gerald Schwerdt,Hans Oberleithner,Hans Oberleithner +8 more
TL;DR: It is concluded that cell polarity and basolateral transport mechanisms are essential in nephrotoxicity of platinum drugs.
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Endothelial Cell Swelling by Aldosterone
Hans Oberleithner,Stefan W. Schneider,Lars Albermann,Uta Hillebrand,Thomas Ludwig,Christoph Riethmüller,Victor Shahin,Claudia Schafer,Hermann Schillers +8 more
TL;DR: Aldosterone induces immediate swelling independently of plasma membrane Na+ channels and intracellular mineralocorticoid receptors followed by late mineraloc Corticoid receptor- and Na+-channel-dependent swelling, which is useful for medical applications to prevent aldosterone-induced vasculopathies.
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Differential action of steroid hormones on human endothelium
Hans Oberleithner,Christoph Riethmüller,Thomas Ludwig,Victor Shahin,Christian Stock,Albrecht Schwab,Martin Hausberg,Kristina Kusche,Hermann Schillers +8 more
TL;DR: It is concluded that glucocorticoids strengthen cell-to-cell contacts (`peripheral action'), whereas mineraloc Corticoids enlarge and stiffen cells (`central action'). This could explain the dexamethasone-mediated retention of fluid in the vascular system, and endothelial dysfunction in states of hyperaldosteronism.
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The electrical resistance breakdown assay determines the role of proteinases in tumor cell invasion.
Thomas Ludwig,Rainer Ossig,Susanne Graessel,Marianne Wilhelmi,Hans Oberleithner,Stefan W. Schneider +5 more
TL;DR: It is concluded that exocytosis of soluble proteases causes electrical breakdown of the MDCK monolayer, independently of physical contact between tumor cells and the monolayers.
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High-resistance MDCK-C7 monolayers used for measuring invasive potency of tumour cells.
TL;DR: The high-resistance MDCK-C7 cell clone could serve as a valuable biological assay system to determine electrically the metastatic potency of tumour cells in vitro.