Albrecht Schwab

TL;DR: After presenting general principles by which transport proteins affect cell migration, the role of channels and transporters involved in cell migration is discussed systematically.

TL;DR: By analyzing the trajectories of wild-type and mutated epithelial (transformed Madin–Darby canine kidney) cells, it is shown experimentally that anomalous dynamics characterizes cell migration.

TL;DR: Micropipette analysis is used to show that a normal chemosensory response to PDGF-AA in fibroblasts requires the primary cilium, and suggests that in coordination with cytoskeletal reorganization, the fibroblast primary cILium functions via ciliary PDGFRα signaling to monitor directional movement during wound healing.

TL;DR: The authors found that more than one type of ATP receptor type as well as metabolites of ATP contributed to the migratory responses of macrophages; furthermore, ATP was not released through pannexin-1 proteins, as has been suggested for neutrophils, suggesting that autocrine purinergic receptor signaling may play a general role in regulating the chemotactic responses of immune cells.

TL;DR: In this paper, a review on how this characteristic, acidic tumor micro-and nano-environment controls tumor cell migration is presented, where the authors show that tumor cells cope with hypoxia and the resulting glycolysis by overexpressing the Na+/H+ exchanger NHE1, monocarboxylate transporters MCT1 and/or MCT4, and the carbonic anhydrase CA IX.