T
Thomas Madsen
Researcher at Harvard University
Publications - 3
Citations - 171
Thomas Madsen is an academic researcher from Harvard University. The author has contributed to research in topics: Transcriptome & KDM5A. The author has an hindex of 3, co-authored 3 publications receiving 113 citations.
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Journal ArticleDOI
KDM5 histone demethylase activity links cellular transcriptomic heterogeneity to therapeutic resistance
Kunihiko Hinohara,Hua-Jun Wu,Sébastien Vigneau,Thomas O. McDonald,Kyomi J. Igarashi,Kimiyo N. Yamamoto,Thomas Madsen,Anne Fassl,Shawn Egri,Malvina Papanastasiou,Lina Ding,Guillermo Peluffo,Ofir Cohen,Stephen C. Kales,Madhu Lal-Nag,Ganesha Rai,David J. Maloney,Ajit Jadhav,Anton Simeonov,Nikhil Wagle,Myles Brown,Alexander Meissner,Piotr Sicinski,Jacob D. Jaffe,Rinath Jeselsohn,Alexander A. Gimelbrant,Franziska Michor,Kornelia Polyak +27 more
TL;DR: It is shown that genetic deletion of KDM5A/B or inhibition of K DM5 activity increases sensitivity to anti-estrogens by modulating estrogen receptor (ER) signaling and by decreasing cellular transcriptomic heterogeneity.
Journal ArticleDOI
Fitness variation in isogenic populations leads to a novel evolutionary mechanism for crossing fitness valleys
TL;DR: A stochastic computational model of the dynamics of an asexually reproducing population, such as somatic or cancer cells, crossing a fitness valley is presented and it is found that fitness variation persisting across generations promotes weaker selection against deleterious intermediates, thereby increasing the rate of valley crossing.
Journal ArticleDOI
Efficient computation of the joint probability of multiple inherited risk alleles from pedigree data.
TL;DR: A novel, approximate version of this algorithm, dubbed the peeling and paring algorithm, is proposed, which scales polynomially in the number of loci, which allows extending peeling‐based models to include many genetic loci.