T
Thomas N. Huckerby
Researcher at Lancaster University
Publications - 131
Citations - 2166
Thomas N. Huckerby is an academic researcher from Lancaster University. The author has contributed to research in topics: Radical polymerization & Methyl methacrylate. The author has an hindex of 26, co-authored 131 publications receiving 2123 citations.
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Journal ArticleDOI
Galantamine inhibits β-amyloid aggregation and cytotoxicity
Balpreet Matharu,Gillian M. Gibson,Richard B. Parsons,Thomas N. Huckerby,Susan Moore,Leanne J. Cooper,Robert Millichamp,David Allsop,Brian M. Austen +8 more
TL;DR: There is some evidence that galantamine may not be acting purely as a symptomatic treatment, and disease-modifying effects of the drug could be due to an additional effect on Abeta aggregation and/or toxicity.
Journal ArticleDOI
Conformational equilibria of alpha-L-iduronate residues in disaccharides derived from heparin.
TL;DR: Three-bond proton-proton coupling constants around the IdoA ring were determined under a range of experimental conditions, providing clear evidence for a rapid conformational equilibrium.
Journal ArticleDOI
There are two major types of skeletal keratan sulphates.
Ian A. Nieduszynski,Thomas N. Huckerby,J M Dickenson,Gavin Brown,Gui-Hua Tai,H G Morris,S Eady +6 more
TL;DR: High-field 1H-n.m.r.r.-spectroscopic studies supported by chemical carbohydrate analyses show that skeletal keratan sulphates (KS-II) of bovine origin may be sub-classified into two groups.
Journal ArticleDOI
A fingerprinting method for chondroitin/dermatan sulfate and hyaluronan oligosaccharides
TL;DR: A previously published method for the analysis of glycosaminoglycan disaccharides by high pH anion exchange chromatography has been modified and calibrated and it is confirmed that freshly isolated shark cartilage CS contains significant amounts of the biologically important GlcA2Sbeta(1-3)GalNAc6S structure.
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Periodate oxidation and alkaline degradation of heparin-related glycans
TL;DR: Heparin, heparan sulphate, and various derivatives thereof have been oxidised with periodate with the aim of providing an additional method for the controlled degradation of heparin.