Showing papers by "Thomas Powles published in 2000"
TL;DR: The incidence of ARL has not changed over time, but contributes to a greater percentage of first AIDS-defining illnesses (ADI) in the HAART era, and older age, nadir CD4 count, and no prior HAART use, predict the development of ARl.
192 citations
TL;DR: High grade B cell non-Hodgkin's lymphoma is the second commonest tumour affecting people with HIV and the prognosis remains worse than for immunocompetent patients.
Abstract: Objective: To review the current literature on HIV associated non-Hodgkin's lymphoma.
Methods: A comprehensive Medline/Pubmed search of articles pertaining to HIV associated non-Hodgkin's lymphoma as well as personal experience from the treatment of over 200 patients at the Chelsea and Westminster Hospital, one of the largest centres for the management of HIV disease in Europe.
Conclusion: High grade B cell non-Hodgkin's lymphoma is the second commonest tumour affecting people with HIV. The incidence of this tumour is not declining following the introduction of highly active antiretroviral therapy. Chemotherapy has been employed with modest success in this group of patients; however, the prognosis remains worse than for immunocompetent patients. Advances in molecular genetics and virology have led to a greater understanding of the biology of these tumours. However, these advances have yet to be translated into improvements in the clinical management of patients with AIDS associated non-Hodgkin's lymphoma.
Key Words: AIDS; HIV; non-Hodgkin's lymphoma
45 citations
TL;DR: In people with HIV the response rates are lower, the relapse rates higher, the infectious complications more frequent and the overall survival worse than for HD in the general population.
Abstract: Hodgkin's disease (HD) appears to occur more frequently in people with HIV and within this population HD demonstrates a number of differences. In people with HIV, Epstein-Barr virus (EBV) is found more frequently in Reed-Sternberg cells and mixed cellularity and lymphocyte depleted histological subtypes predominate. Patients with HIV present with more advanced stage HD often with extranodal disease. The prognostic variables for HD in patients with HIV relate to the HIV rather than the HD. In people with HIV the response rates are lower, the relapse rates higher, the infectious complications more frequent and the overall survival worse than for HD in the general population.
29 citations
TL;DR: The molecular genetics of this virus are reviewed in this article and it is shown that a novel gamma herpesvirus was identified in Kaposi's sarcoma lesions.
Abstract: Epidemiological evidence from the early 1990s suggested that a sexually transmitted infectious agent other than the HIV virus was associated with the development of Kaposi's sarcoma in patients with HIV. A novel gamma herpesvirus was identified in Kaposi's sarcoma lesions. The molecular genetics of this virus are reviewed in this article.
3 citations
1 citations