T
Thomas Primiano
Researcher at Johns Hopkins University
Publications - 8
Citations - 554
Thomas Primiano is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Enzyme & Reductase. The author has an hindex of 7, co-authored 8 publications receiving 545 citations.
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Book ChapterDOI
Antioxidant-Inducible Genes
TL;DR: Evidence for several newly identified antioxidant-inducible genes is presented, the proposed mechanisms of antioxidant signal transduction leading to enhanced expression of these enzymes are described, and the mechanisms and consequences of induction of phase 2 xenobiotic-metabolizing enzymes by antioxidants are described.
Journal Article
Intermittent Dosing with Oltipraz: Relationship between Chemoprevention of Aflatoxin-induced Tumorigenesis and Induction of Glutathione S-Transferases
Thomas Primiano,Patricia A. Egner,Thomas R. Sutter,Gary J. Kelloff,B. D. Roebuck,Thomas W. Kensler +5 more
TL;DR: The chemopreventive efficacy achieved by administration of intermittent doses of oltipraz was evaluated in rats and it was found that the volume of liver occupied by glutathione S-transferase (GST)-P positive foci was observed to be decreased > 95%, > 97%, or > 99% in livers of rats receiving once-, twice-weekly or daily oltIPraz treatments, respectively.
Journal ArticleDOI
cDNA cloning, expression and activity of a second human aflatoxin B1-metabolizing member of the aldo-keto reductase superfamily, AKR7A3.
TL;DR: Findings indicate that, depending on the extent of AFB1 dihydrodiol formation, AKR7A may contribute to the protection against AFB1-induced hepatotoxicity.
Journal ArticleDOI
Isolation of cDNAs representing dithiolethione-responsive genes.
TL;DR: The transcriptional activation of ferritin, ribosomal protein, Dig-1 and DIG-2 genes in conjunction with those of carcinogen detoxification enzymes suggests that they participate in the pleiotropic cellular defense response to dithiolethiones that inhibits chemically produced tumorigenesis.
Journal ArticleDOI
Induction of hepatic heme oxygenase-1 and ferritin in rats by cancer chemopreventive dithiolethiones.
TL;DR: Protective actions of D3T against the cytotoxic and carcinogenic consequences of chemicals that exert electrophilic or oxidative stresses may be mediated, in part, by the induction of HO-1, FL and FH.