Showing papers by "Thomas W. Wakefield published in 1999"
TL;DR: Thrombus organization involves neovascularization and leukocyte influx and that IL-8 augments thrombus organizations, and shows that the angiogenic chemokine interleukin-8 (IL-8) augments this study.
123 citations
TL;DR: Results show that the average molecular weight and molecular weight distribution of the LMWH preparation are important parameters affecting their binding with protamine.
55 citations
TL;DR: In patients with few remaining therapeutic options, one can achieve a 6-month assisted patency and competency rate of 78% and 67%, respectively, with an improved clinical outcome.
46 citations
TL;DR: It is proposed to identify those techniques with the greatest clinical potential, to suggest algorithms for the clinical application of non-invasive techniques in the identification of acute deep venous thrombosis and chronic venous insufficiency, and to identify areas of deficient knowledge and potential areas for future research initiatives.
23 citations
TL;DR: Gd-enhanced MRV was found useful in this rat model of stasis-induced venous thrombosis to document inflammation noninvasively and to evaluate the effects of anti-inflammatory interventions during stasis.
Abstract: Venous thrombosis is associated with a significant inflammatory response in the vein wall, which can be imaged noninvasively with gadolinium (Gd)-enhanced magnetic resonance venography (MRV). Interleukin-10 (IL-10), a naturally occurring anti-inflammatory cytokine, has been found to decrease the inflammatory response at the proper dosage and timing of administration. The present study determines if MRV with Gd is useful in a rat model of stasis-induced venous thrombosis to document the anti-inflammatory effects of rIL-10. Rats underwent laparotomy and ligation of the inferior vena cava (IVC). Animals were infused with rIL-10 at 2.5mug (n=6), rIL-10 at 10mug (n=6), or rIL-10 at40mug (n=6). Six animals without IVC ligation or drug infusion served as controls. Two days after thrombosis induction, the rats underwent MRV with both time-of-flight imaging and pre/post-Gd T1-weighted imaging. Inflammation was analyzed by measuring the area of Gd enhancement at the point of IVC thrombosis. Enhancement area was als...
14 citations