T
Thomas Wallerath
Researcher at University of Mainz
Publications - 17
Citations - 2898
Thomas Wallerath is an academic researcher from University of Mainz. The author has contributed to research in topics: Enos & Nitric oxide synthase. The author has an hindex of 15, co-authored 17 publications receiving 2779 citations. Previous affiliations of Thomas Wallerath include Georgia Regents University.
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Journal ArticleDOI
Resveratrol, a Polyphenolic Phytoalexin Present in Red Wine, Enhances Expression and Activity of Endothelial Nitric Oxide Synthase
Thomas Wallerath,Göran Deckert,Thomas Ternes,Henrik Anderson,Huige Li,Klaus Witte,Ulrich Förstermann +6 more
TL;DR: In concert with other effects, the stimulation of eNOS expression and activity may contribute to the cardiovascular protective effects attributed to resveratrol.
Journal ArticleDOI
Down-regulation of the expression of endothelial NO synthase is likely to contribute to glucocorticoid-mediated hypertension.
Thomas Wallerath,Klaus Witte,Stephan C. Schäfer,Petra Schwarz,Winfried Prellwitz,Paulus Wohlfart,Hartmut Kleinert,Hans-Anton Lehr,Björn Lemmer,Ulrich Förstermann +9 more
TL;DR: Plasma NO(2)(-)/NO(3)(-) (the oxidation products of NO) decreased to 40%, and the expression of endothelial NO synthase (NOS III) was found down-regulated in the aorta and several other tissues of glucocorticoid-treated rats, suggesting the expressional down-regulation of endothelium NOS III may contribute to the hypertension caused by glucOCorticoids.
Journal ArticleDOI
Estrogens increase transcription of the human endothelial NO synthase gene: analysis of the transcription factors involved.
Hartmut Kleinert,Thomas Wallerath,Christian Euchenhofer,Irmgard Ihrig-Biedert,Huige Li,Ulrich Förstermann +5 more
TL;DR: Nuclear run-on assays and transient transfection experiments suggest that the estrogen stimulation of the NOS III promoter could be mediated in part by an increased activity of transcription factor Sp1.
Journal ArticleDOI
Physiological mechanisms regulating the expression of endothelial-type NO synthase
TL;DR: This review summarizes the recent findings in the regulated expression of endothelial nitric oxide synthase and investigates transcriptional and posttranscriptional mechanisms involved in the expressional regulation of this enzyme.
Journal ArticleDOI
Red wine increases the expression of human endothelial nitric oxide synthase: a mechanism that may contribute to its beneficial cardiovascular effects.
TL;DR: The increase in eNOS expression and activity brought about by red wines from France (and probably other locations) may contribute to the beneficial effects of this beverage on the cardiovascular system.