T
Tia M. Hughes
Researcher at Vanderbilt University Medical Center
Publications - 1
Citations - 803
Tia M. Hughes is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Drug resistance. The author has an hindex of 1, co-authored 1 publications receiving 469 citations.
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An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.
Timothy P. Sheahan,Amy C. Sims,Shuntai Zhou,Rachel L. Graham,Andrea J. Pruijssers,Maria L. Agostini,Sarah R. Leist,Alexandra Schäfer,Kenneth H. Dinnon,Laura J. Stevens,James D. Chappell,Xiaotao Lu,Tia M. Hughes,Amelia S. George,Collin S. Hill,Stephanie A. Montgomery,Ariane J. Brown,Gregory R. Bluemling,Michael G. Natchus,Manohar Saindane,Alexander A. Kolykhalov,George R. Painter,Jennifer L Harcourt,Azaibi Tamin,Natalie J. Thornburg,Ronald Swanstrom,Mark R. Denison,Ralph S. Baric +27 more
TL;DR: It is shown that the ribonucleoside analog β-d-N4-hydroxycytidine (NHC; EIDD-1931) has broad-spectrum antiviral activity against SARS- coV-2, MERS-CoV, SARS, and related zoonotic group 2b or 2c bat-CoVs, as well as increased potency against a CoV bearing resistance mutations to the nucleosid analog inhibitor remdesivir