Triazine as a promising scaffold for its versatile biological behavior.

Small-molecule inhibitors can accelerate the functional annotation and validate the therapeutic potential of proteins implicated in disease. Phenotypic screens provide an effective platform to identify such pharmacological agents but are often hindered by challenges associated with target identification. For many protein targets, these bottlenecks can be overcome by incorporating electrophiles into small molecules to covalently trap interactions in vivo and by employing bioorthogonal handles to enrich the protein targets directly from a complex proteome. Here we present the trifunctionalized 1,3,5-triazine as an ideal modular scaffold for generating libraries of irreversible inhibitors with diverse target specificities. A divergent synthetic scheme was developed to derivatize the triazine with an electrophile for covalent modification of target proteins, an alkyne as a click-chemistry handle for target identification, and a diversity element to direct the compounds toward distinct subsets of the proteome....

1,3,5-Triazine as a modular scaffold for covalent inhibitors with streamlined target identification.

The surface coating industry is globally involved in developing useful, eco-friendly, and VOC (volatile organic compounds)-free coating systems, which exhibit promising physico-mechanical and corrosion protective performance. Herein, we report the synthesis of butylated melamine formaldehyde (BMF)-modified soy alkyd (SA-BMF). The structural elucidation and molecular weight of soy alkyd (SA) and SA-BMF resin was carried out by FT-IR, 1H NMR, and 13C NMR spectroscopy and gel permeation chromatography (GPC) techniques. The physico-chemical and physico-mechanical properties were tested by standard protocols. Initial decomposition temperature was measured by thermogravimetric analysis (TGA). The curing study and glass transition temperature were assessed by differential scanning calorimetry (DSC). Hydrophobicity of the coatings was measured in terms of contact angle. The anticorrosion performance of SA-BMF was studied experimentally using polarization techniques and electrochemical impedance spectroscopy (EIS)...

s-Triazine Ring-Modified Waterborne Alkyd: Synthesis, Characterization, Antibacterial, and Electrochemical Corrosion Studies

Structure-activity relationships (SAR) of triazine derivatives: Promising antimicrobial agents.

Synthesis and studies of novel 2-(4-cyano-3-trifluoromethylphenyl amino)-4-(quinoline-4-yloxy)-6-(piperazinyl/piperidinyl)-s-triazines as potential antimicrobial, antimycobacterial and anticancer agents.

Tian Gao

Papers

Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents