T
Tien-Yi Lee
Researcher at Howard Hughes Medical Institute
Publications - 3
Citations - 1607
Tien-Yi Lee is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Azoospermia factor & Azoospermia. The author has an hindex of 2, co-authored 2 publications receiving 1567 citations. Previous affiliations of Tien-Yi Lee include Massachusetts Institute of Technology.
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Journal ArticleDOI
Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA–binding protein gene
Renee Reijo,Tien-Yi Lee,Pia Salo,Raaji Alagappan,Laura G. Brown,Michael A. Rosenberg,Michael A. Rosenberg,Steve Rozen,Tom Jaffe,Donald Straus,Outi Hovatta,Albert de la Chapelle,Sherman J. Silber,David C. Page +13 more
TL;DR: The region contains a single–copy gene, DAZ (Deleted in AZoospermia), which is transcribed in the adult testis and appears to encode an RNA binding protein, and the possibility that DAZ is AZF should now be explored.
Journal ArticleDOI
Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene
Renee Reijo,Tien-Yi Lee,Pia Salo,Raaji Alagappan,Laura G. Brown,Michael A. Rosenberg,Steve Rozen,Tom Jaffe,Donald Straus,Outi Hovatta,Albert de la Chapelle,Sherman J. Silber,David C. Page +12 more
TL;DR: The authors have detected deletions of portions of the Y chromosome long arm in 12 of 89 men with azoospermia (no spermatozoa in their semen), and found no evidence of YRRM genes, recently proposed as AZF candidates in the AZF region.
Journal ArticleDOI
Population PK and Semimechanistic PK/PD Modeling and Simulation of Relugolix Effects on Testosterone Suppression in Men with Prostate Cancer
Tien-Yi Lee,Philippe B. Pierrillas,Yu Wei Lin,Rik de Greef,Anthe S. Zandvliet,E. Schindler,Elizabeth Migoya +6 more
TL;DR: Simulations based on the PopPK and PopPK/PD models were consistent with actual data from clinical studies, reflecting the high predictiveness of the models and supporting the reliability of model-based simulations.