Tom Jaffe

TL;DR: The region contains a single–copy gene, DAZ (Deleted in AZoospermia), which is transcribed in the adult testis and appears to encode an RNA binding protein, and the possibility that DAZ is AZF should now be explored.

TL;DR: The authors have detected deletions of portions of the Y chromosome long arm in 12 of 89 men with azoospermia (no spermatozoa in their semen), and found no evidence of YRRM genes, recently proposed as AZF candidates in the AZF region.

TL;DR: In testes of wildtype mice, Dazh transcription is detectable 1 day after birth, increases steadily as spermatogonial stem cells appear, plateaus as the first wave of sperMatogenic cells enters meiosis, and is sustained at this level thereafter, suggesting that DazH participates in differentiation, proliferation, or maintenance of germ cell founder populations before, during, and after the pubertal onset of sPermatogenesis.

TL;DR: The identified pathogenic and likely pathogenic SNVs and CNVs in 15 patients with unexplained SPGF equals the detection rate of conventional testing for aneuploidies and is considerably higher than the prevalence of Y chromosome microdeletions.