Tim Otto

TL;DR: The findings demonstrate a double dissociation of dorsal and ventral hippocampal function: inactivation of ventral, but not dorsal, hippocampus attenuated the acquisition and expression of trace fear conditioning, whereas in activation of dorsal, butNot ventrals, hippocampus dramatically impaired performance in the delayed reinforced alternation task.

TL;DR: Results provide the first evidence suggesting that NMDA receptor-dependent expression of the IEG Arc in both DH and VH likely underlies the consolidation of a variety of forms of hippocampus-dependent learning.

TL;DR: The results uncover PAC1 signaling as an important factor in the development and/or functioning of neural pathways associated with pheromone processing and the regulation of social interactions in mice and raise the potential clinical relevance of PACAP signaling dysfunctions in neuropsychiatric disorders characterized by social reciprocity impairments such as autism spectrum disorders.

TL;DR: The results of these studies suggest that selectively manipulating the integrity of individual subregions may result in compensatory mechanisms that can support learning, and that NMDA‐dependent plasticity within both dorsal and ventral hippocampus is normally required for the acquisition and maintenance of memory in trace and contextual fear conditioning.

TL;DR: The data suggest that the hippocampus is necessary for behavioral outcomes based on encoding or comparison that affect approach behavior, but not for such outcomes that affect consummatory behavior.