Timo Hillebrand

TL;DR: Analysis of apoptosis signaling pathways (here, p53 in concert with its downstream death effector, BAX) might yield more prognostic power in future studies as compared with analysis of single genes such as p53 alone.

TL;DR: The combined analysis of BAX and p16(ink4a/CDKN2) shows subgroups in SCC of the esophagus with favorable or poor prognosis, suggesting that such a multimarker analysis of apoptosis pathways could be useful for individualization of therapeutic strategies in the future.

TL;DR: A universal process for extracting and purifying nucleic acids from extremely small amounts of highly contaminated various biological and other starting materials is described in this article, which has applications in forensic medicine, medical diagnosis, molecular biology, biochemistry, genetic technology and all related fields.

TL;DR: It is suggested that the tumour proliferative index is a useful predictor of aggressive tumour behaviour and an indicator of patient survival.

TL;DR: In the subset of BAX‐expressing tumors, the mutational inactivation of p53 did result in a reduced BAX protein expression (Fisher exact test, p = 0.047), and additional, not yet identified regulators, apart from p53, appear to be involved in the regulation of BAx protein expression.