T
Timo Lehto
Researcher at University of Helsinki
Publications - 6
Citations - 268
Timo Lehto is an academic researcher from University of Helsinki. The author has contributed to research in topics: Excretion & Complement system. The author has an hindex of 5, co-authored 5 publications receiving 245 citations.
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Structural composition and functional characterization of soluble CD59: heterogeneity of the oligosaccharide and glycophosphoinositol (GPI) anchor revealed by laser-desorption mass spectrometric analysis.
TL;DR: The site of cleavage between the diradylglycerol phosphate and inositol suggests that a mammalian phospholipase D could be involved in the solubilization of GPI-anchored proteins and demonstrates that theospholipid tail is needed for the full functional activity of CD59.
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Urinary excretion of protectin (CD59), complement SC5b-9 and cytokines in membranous glomerulonephritis
TL;DR: It is speculated that the increased excretion of CD59 into urine in patients with idiopathic membranous glomerulonephritis is due to complement activation and inflammation induced shedding ofCD59 from glomerular cells.
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Detection of a Soluble Form of the Complement Membrane Attack Complex Inhibitor CD59 in Plasma after Acute Myocardial Infarction
TL;DR: The results suggest that myocardial damage leads to release of CD59 from the sarcolemmal cell membranes during AMI, which is correlated with the level of soluble terminal complement complexes in the plasmas of AMI patients.
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Activation of the terminal complement cascade in renal infarction.
TL;DR: The deposition and distribution of various C components and regulators and regulators in human renal infarction lesions were studied by indirect immunofluorescence microscopy and the expression of cell membrane-associated protectin was diminished in tubular epithelial cells of the infarctions lesions.
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Urinary excretion of cytokines and complement SC5b-9 in idiopathic membranous glomerulonephritis
TL;DR: The excretion of all cytokines, TNF-alpha in particular, was significantly higher in patients with a progressive disease than in the other patients and no significant correlation with corresponding serum values was observed for urinary IL-6 or T NF-alpha excretion.