S
Seppo Meri
Researcher at University of Helsinki
Publications - 383
Citations - 20678
Seppo Meri is an academic researcher from University of Helsinki. The author has contributed to research in topics: Complement system & Factor H. The author has an hindex of 78, co-authored 358 publications receiving 18915 citations. Previous affiliations of Seppo Meri include University of Texas at Austin & Medical Research Council.
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Journal Article
Human protectin (CD59), an 18,000-20,000 MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayers.
Seppo Meri,Bryan Paul Morgan,A Davies,R H Daniels,M G Olavesen,Herman Waldmann,P. J. Lachmann +6 more
TL;DR: The results demonstrate directly that protectin is a powerful inhibitor of complement cytolysis and acts by inhibiting the C5b-8 catalysed insertion of C9 into the lipid bilayer.
Journal ArticleDOI
Discrimination between activators and nonactivators of the alternative pathway of complement: regulation via a sialic acid/polyanion binding site on factor H.
Seppo Meri,Michael K. Pangburn +1 more
TL;DR: Observations suggest that occupation of a specific site on factor H by polyanions induces an increase in the C3b-H affinity, resulting in discrimination of host cells and tissues from alternative pathway-activating foreign cells.
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Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation
M. Kathryn Liszewski,Martin Kolev,Gaelle Le Friec,Marilyn K. Leung,Paula Bertram,Antonella F. Fara,Marta Subias,Matthew C. Pickering,Christian Drouet,Seppo Meri,T. Petteri Arstila,Pirkka T. Pekkarinen,Margaret H. Y. Ma,Margaret H. Y. Ma,Andrew P. Cope,Andrew P. Cope,Thomas Reinheckel,Santiago Rodríguez de Córdoba,Behdad Afzali,Behdad Afzali,John P. Atkinson,Claudia Kemper +21 more
TL;DR: It was found that the T cell-expressed protease cathepsin L (CTSL) processed C3 into biologically active C3a and C3b, which was observed in all examined cell populations, suggesting that intracellular complement activation might be of broad physiological significance.
Journal ArticleDOI
Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome
Tamara Manuelian,Jens Hellwage,Seppo Meri,Jessica Caprioli,Marina Noris,Stefan Heinen,Mihály Józsi,Hartmut P. H. Neumann,Giuseppe Remuzzi,Peter F. Zipfel +9 more
TL;DR: In this article, three mutations (E1172Stop, R1210C, and R1215G) were identified in the C-terminal region of the complement regulator factor H and each of the three mutations caused reduced binding to the central complement component C3b/C3d.
Journal ArticleDOI
The complement regulator factor H binds to the surface protein OspE of Borrelia burgdorferi.
Jens Hellwage,Taru Meri,Tero Heikkilä,Antti Alitalo,Jaana Panelius,Jaana Panelius,Pekka Lahdenne,Ilkka Seppälä,Ilkka Seppälä,Seppo Meri,Seppo Meri +10 more
TL;DR: Specific binding of factor H to B. burgdorferi sensu stricto OspE may help the pathogen to evade complement attack and phagocytosis.