Microfabricated integrated circuits revolutionized computation by vastly reducing the space, labor, and time required for calculations. Microfluidic systems hold similar promise for the large-scale automation of chemistry and biology, suggesting the possibility of numerous experiments performed rapidly and in parallel, while consuming little reagent. While it is too early to tell whether such a vision will be realized, significant progress has been achieved, and various applications of significant scientific and practical interest have been developed. Here a review of the physics of small volumes (nanoliters) of fluids is presented, as parametrized by a series of dimensionless numbers expressing the relative importance of various physical phenomena. Specifically, this review explores the Reynolds number Re, addressing inertial effects; the Peclet number Pe, which concerns convective and diffusive transport; the capillary number Ca expressing the importance of interfacial tension; the Deborah, Weissenberg, and elasticity numbers De, Wi, and El, describing elastic effects due to deformable microstructural elements like polymers; the Grashof and Rayleigh numbers Gr and Ra, describing density-driven flows; and the Knudsen number, describing the importance of noncontinuum molecular effects. Furthermore, the long-range nature of viscous flows and the small device dimensions inherent in microfluidics mean that the influence of boundaries is typically significant. A variety of strategies have been developed to manipulate fluids by exploiting boundary effects; among these are electrokinetic effects, acoustic streaming, and fluid-structure interactions. The goal is to describe the physics behind the rich variety of fluid phenomena occurring on the nanoliter scale using simple scaling arguments, with the hopes of developing an intuitive sense for this occasionally counterintuitive world.

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Microfluidics: Fluid physics at the nanoliter scale

Electrowetting has become one of the most widely used tools for manipulating tiny amounts of liquids on surfaces. Applications range from 'lab-on-a-chip' devices to adjustable lenses and new kinds of electronic displays. In the present article, we review the recent progress in this rapidly growing field including both fundamental and applied aspects. We compare the various approaches used to derive the basic electrowetting equation, which has been shown to be very reliable as long as the applied voltage is not too high. We discuss in detail the origin of the electrostatic forces that induce both contact angle reduction and the motion of entire droplets. We examine the limitations of the electrowetting equation and present a variety of recent extensions to the theory that account for distortions of the liquid surface due to local electric fields, for the finite penetration depth of electric fields into the liquid, as well as for finite conductivity effects in the presence of AC voltage. The most prominent failure of the electrowetting equation, namely the saturation of the contact angle at high voltage, is discussed in a separate section. Recent work in this direction indicates that a variety of distinct physical effects?rather than a unique one?are responsible for the saturation phenomenon, depending on experimental details. In the presence of suitable electrode patterns or topographic structures on the substrate surface, variations of the contact angle can give rise not only to continuous changes of the droplet shape, but also to discontinuous morphological transitions between distinct liquid morphologies. The dynamics of electrowetting are discussed briefly. Finally, we give an overview of recent work aimed at commercial applications, in particular in the fields of adjustable lenses, display technology, fibre optics, and biotechnology-related microfluidic devices.

/pdf/electrowetting-from-basics-to-applications-14e6zoxse5.pdf

Electrowetting: from basics to applications

The meniscus between two immiscible liquids can be used as an optical lens. A change in curvature of this meniscus by electrowetting leads to a change in focal distance. It is demonstrated that two liquids in a tube form a self-centered lens with a high optical quality. The motion of the lens during a focusing action was studied by observation through the transparent tube wall. Finally, a miniature achromatic camera module was designed and constructed based on this adjustable lens, showing that it is excellently suited for use in portable applications.

/pdf/variable-focus-liquid-lens-for-miniature-cameras-4q0yqyjdbv.pdf

Variable-focus liquid lens for miniature cameras

A near-to-eye display system for forming an image as an illuminated region on a retina of at least one eye of a user is disclosed. The system includes a source of modulated light, a proximal optic positionable adjacent an eye of the user to receive the modulated light. The proximal optic has a plurality of groups of optically redirecting regions. The optically redirecting regions are configured to direct a plurality of beams of the modulated light into a pupil of the eye to form a contiguous illuminated portion of the retina of the eye. A first group of the optically redirecting regions is configured to receive modulated light from the source and redirect beams of the modulated light into the pupil of the eye for illumination of a first portion of the retina. A second group of the optically redirecting regions is configured to receive modulated light from the source and redirect beams of the modulated light into the pupil of the eye for illumination of a second portion of the retina.

Near to eye display system and appliance

A medical sensor may be adapted to account for factors that cause irregularities in pulse oximetry measurements or other spectrophotemetric measurements. Sensors are provided with surface features that reduce the amount of outside light or shunted light that impinge the detecting elements of the sensor. The sensor is adapted to reduce the effect of outside light or shunted light on pulse oximetry measurements.

Medical sensor and technique for using the same

A tunable liquid microlens includes an insulating layer, a droplet of a transparent conducting liquid disposed on a first surface of the insulating layer and a plurality of electrodes insulated from the droplet by the insulating layer. The plurality of electrodes are disposed such that they may be selectively biased to create a respective voltage potential between the droplet and each of the plurality of electrodes, whereby a contact angle between the droplet and the first surface is variable and the droplet may be repositioned along the first surface.

Tunable liquid microlens

A tunable liquid microlens includes an insulating layer, a droplet of a transparent conducting liquid, and a lubricating layer disposed on a first surface of the insulating layer and between the droplet and the insulating layer. The microlens also includes a plurality of electrodes insulated from the droplet by the insulating layer and the lubricating layer, the plurality of electrodes being disposed such that they may be selectively biased to create a respective voltage potential between the droplet and each of the plurality of electrodes, whereby an angle between the droplet and a plane parallel to the first surface of the insulating layer may be varied and the droplet may be repositioned relative to the insulating layer.

Tunable liquid microlens with lubrication assisted electrowetting

A microlens of the present invention may include a liquid droplet whose position and/or surface curvature may be changed (tuned), e.g., by selectively biasing one or more electrodes configured to said droplet. The droplet may then be solidified to fix a desired configuration (e.g., focal length) of the microlens. In one embodiment, the droplet has an optically curable liquid adhesive that is polymerized under exposure to UV light. Microlenses of the present invention may be used, for example, in optical devices to obtain and then maintain optimal coupling between various optical components.

Solidifiable tunable liquid microlens

A tunable microlens uses a layer of photo-conducting material which results in a voltage differential between at least one of a plurality of electrodes and a droplet of conducting liquid when a light beam is incident upon the photo-conducting material Such droplet, which forms the optics of the microlens, moves toward an electrode with higher voltage relative to other electrodes in the microlens Thus, for example, when the light beam is misaligned with the microlens, the voltage differential causes the droplet, and hence the microlens, to realign itself with the beam

Method and apparatus for aligning a photo-tunable microlens

A tunable microlens uses at least two layers of electrodes and a droplet of conducting liquid. Such a droplet, which forms the optics of the microlens, moves toward an electrode with a higher voltage relative to other electrodes in the microlens. When calibration of the microlens is desired, an equal and constant voltage is passed over the first layer of electrodes and a different, constant voltage is passed over the second layer of electrodes, which may, for example, be disposed in a star-like pattern. A driving force relative to each electrode in the second layer results and is proportional to the length of the circumference of the droplet that intersects with each of the electrodes. This driving force reaches equilbrium, and hence the droplet reaches its nominal centered position relative to the second layer of electrodes, when the length of intersection of the circumference of the droplet with each of the electrodes in the second layer is equal.

Timofei Nikita Kroupenkine

Papers

Tunable liquid microlens

Tunable liquid microlens with lubrication assisted electrowetting

Solidifiable tunable liquid microlens

Method and apparatus for aligning a photo-tunable microlens

Method and apparatus for calibrating a tunable microlens