T
Timothy Goggin
Researcher at Hoffmann-La Roche
Publications - 28
Citations - 1378
Timothy Goggin is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Population & Pharmacokinetics. The author has an hindex of 17, co-authored 28 publications receiving 1337 citations. Previous affiliations of Timothy Goggin include University College Cork.
Papers
More filters
Journal ArticleDOI
A prospective study between carbamazepine, phenytoin and sodium valproate as monotherapy in previously untreated and recently diagnosed patients with epilepsy.
TL;DR: Patients with previously untreated epilepsy were randomised to sodium valproate, phenytoin or carbamazepine as monotherapy and followed up for a median period which ranged from 14 to 24 months.
Journal ArticleDOI
Withdrawal of anticonvulsant drugs in patients free of seizures for two years. A prospective study.
TL;DR: It is concluded that withdrawal of anticonvulsant medication should be considered in patients free of seizures for two years, and among the various types of seizures, complex partial seizures with secondary generalization carried the worst prognosis.
Journal Article
Effect of hepatic dysfunction due to liver metastases on the pharmacokinetics of capecitabine and its metabolites.
Chris Twelves,Robert Glynne-Jones,Jim Cassidy,Johannes Schüller,Timothy Goggin,Brigitte Roos,Ludger Banken,Masahiro Utoh,Erhard Weidekamm,Bruno Reigner +9 more
TL;DR: Mild to moderate hepatic dysfunction had no clinically significant influence on the pharmacokinetic parameters of capecitabine and its metabolites, and there is no need for, a priori, adjustment of the dose.
Journal ArticleDOI
A comparative study of the relative influence of different anticonvulsant drugs, UV exposure and diet on vitamin D and calcium metabolism in out-patients with epilepsy.
TL;DR: In this article, the biochemical parameters associated with vitamin D metabolism, calcium, 25-hydroxy-vitamin D (25OHD) and alkaline phosphatase levels were assessed in 226 outpatients with epilepsy.
Journal ArticleDOI
A Comprehensive Hepatitis C Viral Kinetic Model Explaining Cure
Eric Snoeck,Pascal Chanu,Marc Lavielle,Philippe Jacqmin,E. N. Jonsson,Karin Jorga,Timothy Goggin,Joseph F. Grippo,Nelson L. Jumbe,Nicolas Frey +9 more
TL;DR: The proposed viral kinetic model provides a framework for mechanistic exploration of treatment outcome and permits evaluation of alternative CHC treatment options with the ultimate aim of developing and testing hypotheses for personalizing treatments in this disease.