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Timothy J. Young
Researcher at Dow Chemical Company
Publications - 18
Citations - 1491
Timothy J. Young is an academic researcher from Dow Chemical Company. The author has contributed to research in topics: Aqueous solution & Supercritical fluid. The author has an hindex of 11, co-authored 17 publications receiving 1436 citations. Previous affiliations of Timothy J. Young include University of Texas System & University of Texas at Austin.
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Process for production of nanoparticles and microparticles by spray freezing into liquid
Robert O. Williams,Keith P. Johnston,Timothy J. Young,True L. Rogers,Melisa K. Barron,Zhongshui Yu,Jiahui Hu +6 more
TL;DR: In this paper, the authors present a system and a method for the production of microparticles and nanoparticles of materials that can be dissolved, which in turn produces a more uniform distribution of particle sizes, smaller particles, particles with increased porosity and a more intimate mixing of the particle components.
Journal ArticleDOI
Microencapsulation of proteins by rapid expansion of supercritical solution with a nonsolvent
Kenji Mishima,Kiyoshi Matsuyama,Daisaku Tanabe,Satoru Yamauchi,Timothy J. Young,Keith P. Johnston +5 more
TL;DR: In this article, a new method-rapid expansion from supercritical solution with a nonsolvent (RESS-N) is reported for forming polymer microparticles containing proteins such as lysozyme (from chicken egg white) and lipase (from Pseudomonas cepacia).
Journal ArticleDOI
Preparation of cyclosporine A nanoparticles by evaporative precipitation into aqueous solution.
TL;DR: N nanoparticle suspensions of a poorly water-soluble drug, cyclosporine A, are produced by a new process, evaporative precipitation into aqueous solution (EPAS), with the potential for high dissolution rates due to the low crystallinity, small particle size and hydrophilic stabilizer that enhances wetting.
Journal ArticleDOI
Rapid expansion from supercritical to aqueous solution to produce submicron suspensions of water-insoluble drugs.
Timothy J. Young,Simon Mawson,Keith P. Johnston,Inge B. Henriksen,Gary W. Pace,Awadhesh K. Mishra +5 more
TL;DR: To minimize growth of the cyclosporine particles, which would otherwise occur in the free jet expansion, the solution was sprayed into an aqueous Tween‐80 (Polysorbate‐80) solution, which impedes particle growth and agglomeration.
Journal ArticleDOI
A novel particle engineering technology to enhance dissolution of poorly water soluble drugs: spray-freezing into liquid.
True L. Rogers,Andrew C. Nelsen,Jiahui Hu,Judith N Brown,Marazban Sarkari,Timothy J. Young,Keith P. Johnston,Robert O. Williams +7 more
TL;DR: Results indicated that micronized SFL inclusion complex powders dissolved faster in aqueous dissolution media than inclusion complexes formed by conventional techniques due to higher surface areas and stabilized inclusion complexes obtained by ultra-rapid freezing.