T
Tobias Rydén
Researcher at University of Gothenburg
Publications - 6
Citations - 109
Tobias Rydén is an academic researcher from University of Gothenburg. The author has contributed to research in topics: Bone marrow & Imaging phantom. The author has an hindex of 4, co-authored 6 publications receiving 54 citations. Previous affiliations of Tobias Rydén include Sahlgrenska University Hospital.
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Journal ArticleDOI
Bone Marrow Absorbed Doses and Correlations with Hematologic Response During 177Lu-DOTATATE Treatments Are Influenced by Image-Based Dosimetry Method and Presence of Skeletal Metastases
Linn Hagmarker,Johanna Svensson,Tobias Rydén,Martijn van Essen,Anna Sundlöv,Katarina Sjögreen Gleisner,Peter Gjertsson,Peter Bernhardt +7 more
TL;DR: The estimated bone marrow absorbed doses by image-based techniques and the correlation with platelets are influenced by the choice of measured vertebrae and the presence of skeletal metastases.
Journal ArticleDOI
First-in-Humans Application of 161Tb: A Feasibility Study Using 161Tb-DOTATOC.
Richard P. Baum,Aviral Singh,Harshad R. Kulkarni,Peter Bernhardt,Peter Bernhardt,Tobias Rydén,Tobias Rydén,Christiane Schuchardt,Nadezda Gracheva,Pascal V. Grundler,Ulli Köster,Dirk Müller,Michael Pröhl,Jan Rijn Zeevaart,Roger Schibli,Roger Schibli,Nicholas P. van der Meulen,Cristina Müller +17 more
TL;DR: The feasibility to image even small metastases after injection of relatively low activities of 161Tb-DOTATOC using γ-scintigraphy and SPECT is demonstrated and further efforts will be directed towards the application of 161 Tb for therapeutic purposes.
Journal ArticleDOI
Fast GPU-based Monte Carlo code for SPECT/CT reconstructions generates improved 177 Lu images.
Tobias Rydén,Tobias Rydén,J. Heydorn Lagerlöf,J. Hemmingsson,Ida Marin,Johanna Svensson,Magnus Båth,Magnus Båth,Peter Gjertsson,Peter Bernhardt,Peter Bernhardt +10 more
TL;DR: A highly parallel Monte Carlo code for fast, ordered subset expectation maximum (OSEM) reconstructions of SPECT/CT images was developed and reconstructed patient images of 177Lu-DOTATATE treatments revealed clearly improved resolution and contrast.
Journal ArticleDOI
Segmentation of Whole-Body Images into Two Compartments in Model for Bone Marrow Dosimetry Increases the Correlation with Hematological Response in 177Lu-DOTATATE Treatments
TL;DR: The dosimetry method was robust, with an optimal nNUF value of 0.1-0.2, and stronger correlation was found between absorbed dose to BM and hematological response using the two-compartment method, which has potential as a valuable image-based alternative to blood-based BM Dosimetry.
Journal ArticleDOI
Optimizing the Schedule of PARP Inhibitors in Combination with 177Lu-DOTATATE: A Dosimetry Rationale.
Andreas Hallqvist,Johanna Svensson,Linn Hagmarker,Ida Marin,Tobias Rydén,Jean-Mathieu Beauregard,Peter Bernhardt,Peter Bernhardt +7 more
TL;DR: In this article, the authors investigated how to enhance 177Lu-DOTATATE by optimal timing of the addition of a poly-[ADP-ribose]-polymerase (PARP) inhibitor to decrease the ability of tumour cells to repair 177Luinduced DNA damage.